S -Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells

Histone H3.3 was identified as an arsenic-binding protein of S -dimethylarsino-glutathione (ZIO-101, darinaparsin®) in leukemia cells by GE-ICP-MS. Such a binding results in TRAIL-induced apoptosis. We further validate histone H3.3 as a vital target for ZIO-101, offering new information on the mode...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-10, Vol.55 (87), p.13120-13123
Main Authors: Xu, Xiaohan, Wang, Haibo, Li, Hongyan, Hu, Xuqiao, Zhang, Yu, Guan, Xinyuan, Toy, Patrick H., Sun, Hongzhe
Format: Article
Language:English
Subjects:
Anticancer properties
Apoptosis
Arsenic
Glutathione
Histones
Leukemia
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Summary:Histone H3.3 was identified as an arsenic-binding protein of S -dimethylarsino-glutathione (ZIO-101, darinaparsin®) in leukemia cells by GE-ICP-MS. Such a binding results in TRAIL-induced apoptosis. We further validate histone H3.3 as a vital target for ZIO-101, offering new information on the mode of action of arsenic-based anticancer agents.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc07605k