Safety of first year vaccination in children born to mothers with inflammatory bowel disease and exposed in utero to anti‐TNFα agents: a French nationwide population‐based cohort

Summary Background Children born to mothers with IBD may be exposed to anti‐TNFα agents antenatally. Current European guidelines recommend postponing live vaccines until after 6 months of life in this population. Data on the safety of live vaccines administration in the first year of life of these c...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2019-12, Vol.50 (11-12), p.1181-1188
Main Authors: Luu, Maxime, Benzenine, Eric, Barkun, Alan, Doret, Muriel, Michiels, Christophe, Degand, Thibault, Quantin, Catherine, Bardou, Marc
Format: Article
Language:English
Subjects:
Adult
Bacillus Calmette-Guerin vaccine
BCG
BCG Vaccine - therapeutic use
Children
Cohort Studies
Exposure
Female
France
Humans
Immunization
Infant
Infant, Newborn
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - immunology
Intestine
Maternal-Fetal Exchange
Mothers
Pregnancy
Retrospective Studies
Safety
Steroid hormones
Steroids
Steroids - therapeutic use
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor necrosis factor-α
Vaccination - methods
Vaccines
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Summary:Summary Background Children born to mothers with IBD may be exposed to anti‐TNFα agents antenatally. Current European guidelines recommend postponing live vaccines until after 6 months of life in this population. Data on the safety of live vaccines administration in the first year of life of these children are sparse with one reported fatality following bacillus Calmette‐Guerin (BCG) administration. Aims To describe the use and safety of vaccines administered in children born to mothers with IBD and exposed antenatally to anti‐TNFα agents Methods Data from children born to mothers with IBD between 2013 and 2014 were collected retrospectively from the French Health Insurance Database. Vaccines recommended before or at 1 year of age were considered. Results Among 4741 children, 670 (14.1%) were exposed to anti‐TNFα agents antenatally, with concomitant thiopurines in 16.0% (n = 107) and steroids in 19.3% (n = 214). Among these 670 children, 315 (47%) were exposed up to delivery. Exposed children were less likely than non‐exposed to receive BCG (88/670, 13.1% vs 780/4071, 19.2% respectively, P 
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.15504