Bioinformatics analysis of the prognosis and biological significance of HMGB1, HMGB2, and HMGB3 in gastric cancer

• Published in: Journal of cellular physiology 2020-04, Vol.235 (4), p.3438-3446
• Main Authors: Fang, Jian, Ge, Xuhui, Xu, Wenjing, Xie, Jingjing, Qin, Zhongke, Shi, Liqing, Yin, Wenjie, Bian, Maohong, Wang, Hao
• Format: Article
• Language: English
• Subjects: Bioinformatics; Cancer; Cell Line, Tumor; Cell Proliferation; Computational Biology; Confidence intervals; Digestive system; Female; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene regulation; high mobility group boxes; High mobility group proteins; HMGB1 protein; HMGB1 Protein - genetics; HMGB2 Protein - genetics; HMGB3 Protein - genetics; Humans; Male; Medical prognosis; Neoplasia; Prognosis; Progression-Free Survival; Proportional Hazards Models; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Tumors
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.29233

High mobility group box (HMGB) consists primarily of HMGB1, HMGB2, and HMGB3 proteins. Although abnormal HMGB expression is associated with various tumors, the relationship with gastric cancer (GC) remains unclear. In this study, HMGB1, HMGB2, and HMGB3 expression was analyzed using the Oncomine and TCGA databases. Correlations between HMGB1, HMGB2, and HMGB3 and clinicopathological factors were analyzed. cBioPortal was used to analyze HMGB1, HMGB2, and HMGB3 genetic alterations and its gene regulation network in GC tissue. HMGB1, HMGB2, and HMGB3 expression was higher in tumor tissues than in normal tissues, especially in GC. High HMGB1, HMGB2, and HMGB3 expression may predict a poor prognosis among patients with GC (hazard ratios [HR] = 1.90; 95% confidence interval [CI]: [1.30−2.78]) and human digestive system neoplasm (HR = 1.85; 95% CI [1.64−2.10]). These findings suggest that HMGB1, HMGB2, and HMGB3 may be useful prognostic indicators for patients with GC. HMGB1, HMGB2, and HMGB3 expression was higher in tumor tissues than in normal tissues, especially in gastric cancer (GC). High HMGB1, HMGB2, and HMGB3 expression may predict a poor prognosis among patients with GC and human digestive system neoplasm. These findings suggest that HMGB1, HMGB2, and HMGB3 may be useful prognostic indicators for patients with GC.