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Palladium-Catalyzed Carboxylate-Assisted Ethoxycarboxylation of Aromatic Acids To Synthesize Monoethyl Phthalate Derivatives with Ethyl Bromodifluoroacetate

A novel and efficient approach for direct carbonation of aromatic acids with ethyl bromodifluoroacetate as the carbonyl source is reported. A broad range of substrates bearing various functional groups were tolerated, leading to monoalkyl phthalate derivatives in moderate to good yields.

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Bibliographic Details
Published in:Organic letters 2019-11, Vol.21 (21), p.8607-8610
Main Authors: Tao, Na, Wang, Jie, Yuan, Chunchen, Zeng, Runsheng, Zhao, Ying-Sheng
Format: Article
Language:English
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Summary:A novel and efficient approach for direct carbonation of aromatic acids with ethyl bromodifluoroacetate as the carbonyl source is reported. A broad range of substrates bearing various functional groups were tolerated, leading to monoalkyl phthalate derivatives in moderate to good yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b03196