Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe ( PCP-1 ) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-10, Vol.55 (88), p.13267-1327
Main Authors: Kim, Won Young, Won, Miae, Salimi, Abbas, Sharma, Amit, Lim, Jong Hyeon, Kwon, Seung-Hae, Jeon, Joo-Yeong, Lee, Jin Yong, Kim, Jong Seung
Format: Article
Language:English
Subjects:
Metastasis
Oxidase
Prostate cancer
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Summary:Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe ( PCP-1 ) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential. Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc07009e