Revealing new landscape of cardiovascular disease through circular RNA-miRNA-mRNA axis

Non-coding RNA (ncRNA) is a kind of RNA, produced by genomic transcription and does not encode protein, but can regulate the function of genes, thus widely regulating pathological and physiological processes. The dynamic balance of the reticular structure between them is needed to regulate the homeo...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2020-03, Vol.112 (2), p.1680-1685
Main Authors: Su, Qiang, Lv, Xiangwei
Format: Article
Language:English
Subjects:
Animals
Cardiovascular diseases
Cardiovascular Diseases - genetics
CeRNA
CircRNA
Gene Regulatory Networks
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
MiRNA
RNA, Circular - genetics
RNA, Circular - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:Non-coding RNA (ncRNA) is a kind of RNA, produced by genomic transcription and does not encode protein, but can regulate the function of genes, thus widely regulating pathological and physiological processes. The dynamic balance of the reticular structure between them is needed to regulate the homeostasis, the abnormal regulation of one of them may lead to the occurrence of the disease. CircRNA is mainly involved in the evolution of CVD through sponge-like regulation of miRNAs, subsequently regulating miRNAs and their targets, mRNA functions. The role of circRNA–miRNA–mRNA axis in pathogenesis of cardiovascular diseases has been recently reported and highlighted. In this review, the emerging roles of circRNA–miRNA–mRNA axis in cardiovascular pathophysiology and regulation were discussed, with a novel focus on cardioprotective network activities of the circRNA. •circRNA–miRNA–mRNA axis is an important mechanism for in the pathogenesis and development of CVDs. Systematic analysis of circRNA–miRNA–mRNA in CVDs is lacking and greatly needed.•This is the most comprehensive review to explore the current knowledge concerning circRNA–miRNA–mRNA axis in the pathogenesis and development of CVDs and abnormal conditions.•Here, we provided the most systematic analysis so far of circRNA–miRNA–mRNA axis in CVDs, which could promote further mechanism and experimental study.
ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2019.10.006