The Use of Intraperitoneal Bupivacaine in Laparoscopic Roux-en-Y Gastric Bypass: a Double-blind, Randomized Controlled Trial

Background Several studies have shown a reduction in postoperative pain and length of hospital stay when using intraperitoneal local anesthetics during laparoscopic surgery. In morbidly obese patients, respiratory depression due to opioid use is a serious side effect. Any different type of analgesia...

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Bibliographic Details
Published in:Obesity surgery 2019-10, Vol.29 (10), p.3118-3124
Main Authors: Schipper, Iris E., Schouten, Manon, Yalcin, Tugba, Algie, Gijs D., Damen, Stefan L., Smeenk, Robert M., Schouten, Ruben
Format: Article
Language:English
Subjects:
Adult
Aerosols
Analgesics, Opioid - therapeutic use
Anesthetics, Local - therapeutic use
Antiemetics - therapeutic use
Bupivacaine - therapeutic use
Double-Blind Method
Double-blind studies
Drug Utilization - statistics & numerical data
Female
Gastric Bypass
Gastrointestinal surgery
Health risk assessment
Humans
Injections, Intraperitoneal
Laparoscopy
Length of Stay - statistics & numerical data
Local anesthesia
Male
Medicine
Medicine & Public Health
Middle Aged
Narcotics
Obesity
Original Contributions
Pain
Pain, Postoperative - drug therapy
Patients
Prospective Studies
Surgery
Visual Analog Scale
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Summary:Background Several studies have shown a reduction in postoperative pain and length of hospital stay when using intraperitoneal local anesthetics during laparoscopic surgery. In morbidly obese patients, respiratory depression due to opioid use is a serious side effect. Any different type of analgesia is therefore clinically relevant. Objective To assess the effect of intraperitoneal bupivacaine on postoperative pain after laparoscopic Roux-en-Y gastric bypass (LRYGB). Methods Between March and November 2017, 130 patients were included and randomly assigned to receive 20 ml or 0 ml of 2.5% bupivacaine hydrochloride sprayed onto the diaphragm. Pain scores for abdominal and shoulder pain were conducted using the visual analogue scale (VAS) for pain score at 0, 1, 6, and 24 h postoperatively. The length of hospital stay and use of analgesics was recorded in digital patient records. The primary outcome is the pain scores and the secondary outcomes are postoperative use of opioids or antiemetics and length of hospital stay. Results The study and control group contained respectively 66 and 61 patients. Patient characteristics were equal in both groups ( p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-019-03982-6