Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms

• Published in: The Science of the total environment 2020-01, Vol.700, p.134391-134391, Article 134391
• Main Authors: Yin, Jun-Fa, Li, Ji-Fang-Tong, Li, Xing-Hong, Yang, You-Lin, Qin, Zhan-Fen
• Format: Article
• Language: English
• Subjects: Adipose tissue; Adipose Tissue - metabolism; Dechlorane plus; Environmental Monitoring; Environmental Pollutants - metabolism; Humans; Hydrocarbons, Chlorinated - metabolism; Lipids; Polycyclic Compounds - metabolism; Serum
• ISSN: 0048-9697; 1879-1026
• DOI: 10.1016/j.scitotenv.2019.134391

[Display omitted] •The levels of DP and adipose-serum partitioning relationship are reported.•DP partitioning among human tissues is related to lipid-driven mechanism.•Stereo-selective behavior of DP is not found between serum and adipose tissue.•Internal mono-dechlorinated potential of anti-DP might not be predominant in humans. In this study, bioaccumulation and transfer characteristics of dechlorane plus (DP) were examined between human adipose tissue and matched maternal serum, and the possible transfer mechanism between tissues was further discussed. The median level of total DP was 971 pg g−1 wet weight (ww) and 1.22 ng g−1 lipid weight (lw) in adipose tissue, respectively, and was 34.7 pg g−1 ww and 3.98 ng g−1 lw for serum, respectively. DP wet levels’ positive association with fat contents of five types of human tissues indicated that DP distribution might be related to lipid-driven mechanism. However, the lipid-adjusted adipose-serum partitioning ratios were estimated to be 0.35 for syn-DP and 0.35 for anti-DP, accordingly, which implied that the DP distribution between serum and adipose tissues, was not only regulated by the tissue lipid contents. Both the internal mono-dechlorination of anti-DP, and stereo-selective behavior of DP isomers were not found in DP transfer from blood to adipose tissue. The marginal positive relationship was observed between serum levels and apolipoprotein A concentrations (p = 0.095 for total DP and 0.045 for syn-DP), and neither association was found between serum levels and thyroid hormone concentrations (THs). To our best knowledge, this is the first report about the accumulation relationship of DP between human adipose tissue and blood stream with the corresponding distribution-related mechanism.