A possible mechanism of the formation of endolymphatic hydrops and its associated inner ear disorders

The pathology of Meniere’s disease (MD) is well established to be endolymphatic hydrops. However, the mechanism underlying deafness and vertigo of MD or idiopathic endolymphatic hydrops is still unknown. In order to evaluate the pathogenesis of deafness and vertigo in MD, it seems to be rational to...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2020-02, Vol.47 (1), p.25-41
Main Authors: Takeda, Taizo, Takeda, Setsuko, Kakigi, Akinobu
Format: Article
Language:English
Subjects:
Animal model
Endolymphatic hydrops
Hearing loss
Meniere’s disease
Vertigo
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Summary:The pathology of Meniere’s disease (MD) is well established to be endolymphatic hydrops. However, the mechanism underlying deafness and vertigo of MD or idiopathic endolymphatic hydrops is still unknown. In order to evaluate the pathogenesis of deafness and vertigo in MD, it seems to be rational to investigate the interrelationship between hydrops and inner ear disorders using animals with experimentally-induced endolymphatic hydrops. In spite of intense efforts by many researchers, the mechanism of vertiginous attack has been unexplained, because animals with experimental hydrops usually did not show vertiginous attack. Recently, there are two reports to succeed to evoke vertiginous attack in animals with experimental hydrops. In the present paper were first surveyed past proposals about underlying mechanism of the development of hydrops and inner ear disorders associated with hydrops, and were discussed the pathogenetic mechanism of vertiginous attack in hydrops. In conclusion, abrupt development of hydrops was thought to play a pivotal role in the onset of vertiginous seizure.
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2019.09.005