Evaluation of Allergenic, Immunogenic, and Skin-Irritant Effects of Deicing Chemicals in Warm-Blooded Animals

We studied allergenic, immunogenic, and skin-irritating effects of deicing chemicals HCM (Volgograd), Bishofit (Turkmenia), and Nordix-P (Russia) in model experiments on various types of laboratory animals (rats, mice, rabbits). All the studied deicing chemicals exhibited weak immunotoxic activity a...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-09, Vol.167 (5), p.656-659
Main Authors: Vodyanova, M. A., Kryatov, I. A., Chudakova, S. B., Ushakova, O. V., Evseeva, I. S., Makovetskaya, A. K., Mislavsky, O. V.
Format: Article
Language:English
Subjects:
Allergens - pharmacology
Analysis
Animal experimentation
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Deicing chemicals
Epidemiology
Female
Glycerol - pharmacology
Guinea Pigs
Humans
Hypersensitivity, Delayed - chemically induced
Hypersensitivity, Delayed - immunology
Immune response
Immunity, Humoral - drug effects
Internal Medicine
Irritants - pharmacology
Laboratory Medicine
Male
Mice
Mice, Inbred BALB C
Pathology
Rabbits
Rats
Russia
Salts - pharmacology
Skin
Skin - drug effects
Skin - immunology
Transportation
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Summary:We studied allergenic, immunogenic, and skin-irritating effects of deicing chemicals HCM (Volgograd), Bishofit (Turkmenia), and Nordix-P (Russia) in model experiments on various types of laboratory animals (rats, mice, rabbits). All the studied deicing chemicals exhibited weak immunotoxic activity and in high doses can cause delayed-type hypersensitivity reaction that manifested in skin irritant effect on the skin and produced a suppressive effect on the humoral immunity. The modified method for assessing skin irritation proposed by us is more sensitive than standard methods.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04592-z