Induced terreins production from marine red algal-derived endophytic fungus Aspergillus terreus EN-539 co-cultured with symbiotic fungus Paecilomyces lilacinus EN-531

• Published in: Journal of antibiotics 2020-02, Vol.73 (2), p.108-111
• Main Authors: Li, Hong-Lei, Li, Xiao-Ming, Yang, Sui-Qun, Cao, Jin, Li, Yan-He, Wang, Bin-Gui
• Format: Article
• Language: English
• Subjects: 45/22; 45/23; 631/1647/2230/1378; 631/326/22/1290; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Aspergillus - metabolism; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Brief Communication; Coculture Techniques; Cyclopentanes - isolation & purification; Cyclopentanes - pharmacology; E coli; Life Sciences; Medicinal Chemistry; Metabolites; Microbial Sensitivity Tests; Microbiology; Organic Chemistry; Paecilomyces - metabolism; Rhodophyta - microbiology; Secondary Metabolism; Secondary metabolites
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/s41429-019-0242-4

The coculture of marine red algal-derived endophytic fungi Aspergillus terreus EN-539 and Paecilomyces lilacinus EN-531 induced the production of a new terrein derivative, namely asperterrein ( 1 ) and a known dihydroterrein ( 2 ), which were not detected in the axenic cultures of both strains. The production of the known secondary metabolites terrein ( 3 ), butyrolactone I ( 4 ), and dankasterone ( 6 ), derived from A. terreus EN-539, were depressed significantly in the coculture. Compounds 1 – 3 exhibited inhibitory activity against Alternaria brassicae , Escherichia coli , Physalospora piricola , and Staphylococcus aureus with MIC values ranging from 4 to 64 μg ml −1 .