Elicitation of the Swallowing Reflex by Esophageal Stimulation in Healthy Subjects: An Evaluation Using High-Resolution Manometry

The purposes of this human study using high-resolution manometry were to verify whether the swallowing reflex can be evoked by intra-esophageal fluid injection and whether the reflex latency and manometric variables differ depending on the injected location, amount, or speed. Ten healthy individuals...

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Bibliographic Details
Published in:Dysphagia 2020-08, Vol.35 (4), p.657-666
Main Authors: Taniguchi, Hiroshige, Aoyagi, Yoichiro, Matsuo, Koichiro, Imaeda, Sayuri, Hirumuta, Makoto, Saitoh, Eiichi
Format: Article
Language:English
Subjects:
Esophageal sphincter
Esophagus
Gastroenterology
Hepatology
Imaging
Injection
Latency
Medical colleges
Medicine
Medicine & Public Health
Original Article
Otorhinolaryngology
Radiology
Sphincter
Swallowing
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Summary:The purposes of this human study using high-resolution manometry were to verify whether the swallowing reflex can be evoked by intra-esophageal fluid injection and whether the reflex latency and manometric variables differ depending on the injected location, amount, or speed. Ten healthy individuals participated in this study. The tip of the intranasal catheter for injection was placed at 5 cm (upper), 10 cm (upper-middle), 15 cm (lower-middle), or 20 cm (lower) from the distal end of the upper esophageal sphincter (UES). An intra-esophageal injection of 3 mL or 10 mL of thickened water was administered and controlled at 3 mL/s or 10 mL/s. Latencies from the start of the injection to the onset of UES relaxation were compared regarding injection locations, amounts, and rates. Manometric variables of intra-esophageal injection and voluntary swallowing were compared. The latency became shorter when the upper region was injected. Latency after the 10-mL injection was shorter than that after the 3-mL injection ( p  
ISSN:0179-051X
1432-0460
DOI:10.1007/s00455-019-10068-z