Clinical and epidemiological characteristics of Coxsackievirus A6- and Enterovirus 71-associated clinical stage 2 and 3 severe hand, foot, and mouth disease in Guangxi, Southern China, 2017

•A total of 2350 severe HFMD cases with mild neurological symptoms were dividing into clinical stage 2 and stage 3.•The dominated pathogens for HFMD clinical stage 2 and 3 were CV-A6 and EV-A71, respectively.•Clinical symptoms preference existed among CV-A6, EV-A71, and CV-A10. Clinical and epidemio...

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Bibliographic Details
Published in:The Journal of infection 2020-01, Vol.80 (1), p.121-142
Main Authors: Ju, Yu, Tan, Zhenlian, Huang, Hao, Chen, Minmei, Tan, Yi, Zhang, Chao, Wang, Jin, Wang, Hong, Chen, Min
Format: Article
Language:English
Subjects:
Antibodies, Viral
China - epidemiology
Clinical features
CV-A6
Enterovirus - genetics
Enterovirus A, Human - genetics
EV-A71
Hand, Foot and Mouth Disease - epidemiology
HFMD
Humans
Severe case
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Summary:•A total of 2350 severe HFMD cases with mild neurological symptoms were dividing into clinical stage 2 and stage 3.•The dominated pathogens for HFMD clinical stage 2 and 3 were CV-A6 and EV-A71, respectively.•Clinical symptoms preference existed among CV-A6, EV-A71, and CV-A10. Clinical and epidemiological features for 2194 stage 2 and 156 stage 3 of hand, foot, and mouth disease (HFMD) cases were characterized and the dominated pathogens were Coxsackievirus A6 (CV-A6) and enterovirus 71(EV-A71), respectively. Our data highlights that CV-A6 is emerging to be a pivotal pathogen for severe HFMD in southern China and clinical symptoms preference may exist among CV-A6, EV-A71, and CV-A10.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2019.09.021