Regulation of angiopoietin-like protein 8 expression under different nutritional and metabolic status

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with increasing prevalence worldwide. Angiopoietin-like protein 8 (ANGPTL8), a member of the angiopoietin-like protein family, is involved in glucose metabolism, lipid metabolism, and energy homeostasis and believed to be associated with...

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Bibliographic Details
Published in:ENDOCRINE JOURNAL 2019, Vol.66(12), pp.1039-1046
Main Authors: Guo, Chang, Zhao, Zhicong, Deng, Xia, Chen, Zian, Tu, Zhigang, Yuan, Guoyue
Format: Article
Language:English
Subjects:
Angiopoietin
Angiopoietin-like 4 Protein - physiology
Angiopoietin-like protein 8 (ANGPTL8)
Angiopoietin-like Proteins - genetics
Angiopoietin-like Proteins - physiology
Animals
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Energy balance
Energy metabolism
Fatty liver
Gene Expression Regulation - physiology
Glucagon-Like Peptide 1 - physiology
Glucose - metabolism
Homeostasis
Humans
Insulin - physiology
Lipase
Lipid Metabolism
Lipoprotein Lipase
Lipoproteins
Liver diseases
Metabolic Diseases - metabolism
Metabolic disorders
Metabolic status
Metabolism
Nutritional status
Nutritional Status - physiology
Peptide Hormones - genetics
Peptide Hormones - physiology
Protein turnover
Proteins
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Summary:Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with increasing prevalence worldwide. Angiopoietin-like protein 8 (ANGPTL8), a member of the angiopoietin-like protein family, is involved in glucose metabolism, lipid metabolism, and energy homeostasis and believed to be associated with T2DM. Expression levels of ANGPTL8 are often significantly altered in metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD) and diabetes mellitus. Studies have shown that ANGPTL8, together with other members of this protein family, such as angiopoietin-like protein 3 (ANGPTL3) and angiopoietin-like protein 4 (ANGPTL4), regulates the activity of lipoprotein lipase (LPL), thereby participating in the regulation of triglyceride related lipoproteins (TRLs). In addition, members of the angiopoietin-like protein family are varyingly expressed among different tissues and respond differently under diverse nutritional and metabolic status. These findings may provide new options for the diagnosis and treatment of diabetes, metabolic syndromes and other diseases. In this review, the interaction between ANGPTL8 and ANGPTL3 or ANGPTL4, and the differential expression of ANGPTL8 responding to different nutritional and metabolic status during the regulation of LPL activity were reviewed.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ19-0263