Copeptin Kinetics in Acute Ischemic Stroke May Differ According to Revascularization Strategies: Pilot Data

BACKGROUND AND PURPOSE—Prognostic value of copeptin in acute ischemic stroke has been widely reported. This study aimed to evaluate copeptin temporal profile according to revascularization strategies and the development of brain edema and hemorrhagic transformation. METHODS—Plasma copeptin and brain...

Full description

Saved in:
Bibliographic Details
Published in:Stroke (1970) 2019-12, Vol.50 (12), p.3632-3635
Main Authors: Spagnolello, Ornella, De Michele, Manuela, Lorenzano, Svetlana, Cerulli Irelli, Emanuele, Naitana, Federico, Falcou, Anne, Letteri, Federica, Bachetoni, Alessandra, Collepardo, Daniela, Bertazzoni, Giuliano, Toni, Danilo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Brain Edema - blood
Brain Edema - diagnostic imaging
Brain Edema - epidemiology
Brain Ischemia - blood
Brain Ischemia - diagnostic imaging
Brain Ischemia - therapy
Cohort Studies
Combined Modality Therapy
Conservative Treatment
Female
Glycopeptides - blood
Humans
Intracranial Hemorrhages - blood
Intracranial Hemorrhages - diagnostic imaging
Intracranial Hemorrhages - epidemiology
Kinetics
Magnetic Resonance Imaging
Male
Middle Aged
Pilot Projects
Prognosis
Prospective Studies
Stroke - blood
Stroke - diagnostic imaging
Stroke - therapy
Thrombectomy
Thrombolytic Therapy
Tomography, X-Ray Computed
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND AND PURPOSE—Prognostic value of copeptin in acute ischemic stroke has been widely reported. This study aimed to evaluate copeptin temporal profile according to revascularization strategies and the development of brain edema and hemorrhagic transformation. METHODS—Plasma copeptin and brain edema and hemorrhagic transformation assessed by computed tomography/magnetic resonance imaging were evaluated upon admission (T0), at 24 hours (T1), and between the third and fifth day of hospitalization (T2) in 34 acute ischemic stroke patients. RESULTS—Median copeptin concentration was 50.71 pmol/L at T0, 18.31 pmol/L at T1, and 10.92 pmol/L at T2. Copeptin at T1 was higher in patients with medium/severe brain edema at T2 (32.25 versus 13.67 pmol/L; P=0.038) and hemorrhagic transformation at T1 (93.10 versus 13.67 pmol/L; P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.119.025433