Association between REM sleep behavior disorder and impulsive–compulsive behaviors in Parkinson’s disease: a systematic review and meta-analysis of observational studies

Background Both REM sleep behavior disorder (RBD) and impulsive–compulsive behaviors (ICBs) are well-recognized non-motor features in patients with Parkinson’s disease (PD). Studies have given contradictory results about the potential association between RBD and ICBs. Methods PubMed, Embase (via Ovi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurology 2020-02, Vol.267 (2), p.331-340
Main Authors: Lu, Hai-tao, Shen, Qiu-yan, Zhao, Quan-zhen, Huang, Hong-yan, Ning, Ping-ping, Wang, Hui, Xie, Dan, Xu, Yan-ming
Format: Article
Language:English
Subjects:
Behavior disorders
Clinical trials
Impulsive behavior
Medicine
Medicine & Public Health
Meta-analysis
Movement disorders
Neurodegenerative diseases
Neurology
Neuroradiology
Neurosciences
Observational studies
Original Communication
Parkinson's disease
REM sleep
Risk factors
Sensitivity analysis
Sleep disorders
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Both REM sleep behavior disorder (RBD) and impulsive–compulsive behaviors (ICBs) are well-recognized non-motor features in patients with Parkinson’s disease (PD). Studies have given contradictory results about the potential association between RBD and ICBs. Methods PubMed, Embase (via Ovid), and the Cochrane Central Registry of Controlled Trials (CENTRAL) databases were systematically searched till August 20, 2019 to identify studies that explored the possible correlation between RBD and ICBs in patients with PD. Two authors independently screened records, extracted data and evaluated quality of included studies. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by employing a random or fixed-effects model. We performed subgroup and sensitivity analyses, and we assessed potential publication bias. Results A total of 134 references were screened and 10 studies involving 2781 PD patients were included. Overall, RBD was associated with a more than twofold higher risk of developing ICBs (OR 2.12, 95% CI 1.43–3.14, I 2  = 56.7%, P  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-019-09588-3