Decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived acrylamides

An oxidative decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived acrylamides was developed. This cascade reaction exhibits a broad substrate scope, and provides an efficient access to carbonyl-containing pyrido[4,3,2- gh ]phenanthridines. A possible mechanism is pr...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2019-11, Vol.17 (43), p.9447-9455
Main Authors: Shang, Jia-Qi, Wang, Xiang-Xiang, Xin, Yangchun, Li, Yi, Zhou, Bin, Li, Ya-Min
Format: Article
Language:English
Subjects:
Acids
Carbonyl compounds
Carbonyls
Cascade chemical reactions
NMR
Nuclear magnetic resonance
Substrates
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Summary:An oxidative decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived acrylamides was developed. This cascade reaction exhibits a broad substrate scope, and provides an efficient access to carbonyl-containing pyrido[4,3,2- gh ]phenanthridines. A possible mechanism is proposed. An oxidative decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived acrylamides delivering carbonyl-containing pyrido[4,3,2- gh ]phenanthridines is presented.
ISSN:1477-0520
1477-0539
DOI:10.1039/c9ob02023c