Perampanel‐induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome

ABSTRACT Antiepileptic drug side effects are frequent, 42% of them corresponding to cosmetic changes. The most frequent effects are weight gain, gingival hyperplasia, and hair loss. Hair changes in texture or colour are rarely reported in the literature. We present a case of hair curling after the i...

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Bibliographic Details
Published in:Epileptic disorders 2019-10, Vol.21 (5), p.479-482
Main Authors: Calle‐Lopez, Yamile, Kotagal, Prakash, Knight, Elia Pestana
Format: Article
Language:English
Subjects:
Adolescent
adverse events
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Antiepileptic agents
antiepileptic drugs
Epilepsy
Epilepsy - drug therapy
Epilepsy - etiology
Etiracetam
Facies
Female
Hair
Hair - anatomy & histology
Hair - drug effects
Humans
Hyperplasia
Hyperventilation - complications
Intellectual Disability - complications
perampanel
Pyridones - adverse effects
Pyridones - therapeutic use
Seizures
Seizures - drug therapy
Side effects
Treatment Outcome
Valproic acid
Valproic Acid - therapeutic use
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Summary:ABSTRACT Antiepileptic drug side effects are frequent, 42% of them corresponding to cosmetic changes. The most frequent effects are weight gain, gingival hyperplasia, and hair loss. Hair changes in texture or colour are rarely reported in the literature. We present a case of hair curling after the introduction of perampanel. A 13‐year‐old girl with genetically confirmed Pitt‐Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control. After a few weeks of the introduction of the new antiepileptic drug, she developed hair curling. Hair curling is a rare cosmetic side effect, reported mainly in patients under valproic acid treatment. Perampanel is a recently introduced pharmaceutical molecule with no prior reports of hair changes as a side effect. There is no clear explanation for this side effect, but it should be discussed with patients taking valproate whenever perampanel is added to the treatment.
ISSN:1294-9361
1950-6945
DOI:10.1684/epd.2019.1103