Clinical effect of double filtration plasmapheresis combined with glucocorticoid and immunosuppressant in treatment of children with severe Henoch-Schönlein purpura nephritis

OBJECTIVETo study the clinical effect and safety of double filtration plasmapheresis (DFPP) combined with double pulse therapy with methylprednisolone (MP) and cyclophosphamide (CTX) in the treatment of children with severe Henoch-Schönlein purpura nephritis (HSPN).METHODSA total of 60 children with...

Full description

Saved in:
Bibliographic Details
Published in:Zhongguo dang dai er ke za zhi 2019-10, Vol.21 (10), p.955-959
Main Authors: Liu, Na, Ma, Zhong-Zheng, Yan, Hui-Fang, Li, Qiong, Lyu, Xiao-Qian, Kang, Wei-Li, Yin, Zhan-Ru
Format: Article
Language:Chinese
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OBJECTIVETo study the clinical effect and safety of double filtration plasmapheresis (DFPP) combined with double pulse therapy with methylprednisolone (MP) and cyclophosphamide (CTX) in the treatment of children with severe Henoch-Schönlein purpura nephritis (HSPN).METHODSA total of 60 children with severe HSPN who were admitted to the hospital from January 2014 to March 2018 were enrolled and were randomly divided into an observation group and a control group (n=30 each). In addition to routine treatment, the children in the control group were given MP+CTX pulse therapy. Those in the observation group were given DFPP treatment in addition to the treatment in the control group, with three courses of treatment in total. After three courses of treatment, the two groups were compared in terms of 24-hour urinary protein, urinary microproteins, renal function parameters, adverse reactions, and clinical outcome.RESULTSAfter three courses of treatment, the observation group had significantly greater reductions in 24
ISSN:1008-8830