Solid lipid nanoparticle-based dissolving microneedles: A promising intradermal lymph targeting drug delivery system with potential for enhanced treatment of lymphatic filariasis

[Display omitted] •We developed solid lipid nanoparticles containing antifilariasis drugs for lymphatic targeting.•We incorporated the nanoparticles into dissolving microneedles for intradermal delivery.•We successfully enhanced the lymphatic targeting of our approach compared to conventional route....

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Bibliographic Details
Published in:Journal of controlled release 2019-12, Vol.316, p.34-52
Main Authors: Permana, Andi Dian, Tekko, Ismaiel A., McCrudden, Maelíosa T.C., Anjani, Qonita Kurnia, Ramadon, Delly, McCarthy, Helen O., Donnelly, Ryan F.
Format: Article
Language:English
Subjects:
Albendazole
Diethylcarbamazine
Doxycycline
Lymphatic filariasis
Microneedles
Solid lipid nanoparticles
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Summary:[Display omitted] •We developed solid lipid nanoparticles containing antifilariasis drugs for lymphatic targeting.•We incorporated the nanoparticles into dissolving microneedles for intradermal delivery.•We successfully enhanced the lymphatic targeting of our approach compared to conventional route.•We successfully reduced the systemic exposure of drugs in organs using our novel approach. Conventional oral therapy of lymphatic filariasis drugs is only effective to kill microfilariae in the bloodstream, but is often ineffective to kill adult filarial (macrofilariae) in the complex anatomy of the lymphatic system. The encapsulation of drugs into lipid-based nanoparticles with sizes of
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2019.10.004