Predicting intestinal recovery after necrotizing enterocolitis in preterm infants

Background Intestinal recovery after NEC is difficult to predict in individuals. We evaluated whether several biomarkers predict intestinal recovery after NEC in preterm infants. Methods We measured intestinal tissue oxygen saturation ( r int SO 2 ) and collected urinary intestinal-fatty acid bindin...

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Bibliographic Details
Published in:Pediatric research 2020-04, Vol.87 (5), p.903-909
Main Authors: Kuik, Sara J., Kalteren, Willemien S., Mebius, Mirthe J., Bos, Arend F., Hulscher, Jan B. F., Kooi, Elisabeth M. W.
Format: Article
Language:English
Subjects:
Biomarkers
Clinical Research Article
Gastrointestinal diseases
Medicine
Medicine & Public Health
Necrosis
Newborn babies
Pediatric Surgery
Pediatrics
Premature babies
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Summary:Background Intestinal recovery after NEC is difficult to predict in individuals. We evaluated whether several biomarkers predict intestinal recovery after NEC in preterm infants. Methods We measured intestinal tissue oxygen saturation ( r int SO 2 ) and collected urinary intestinal-fatty acid binding protein (I-FABP u ) levels 0–24 h and 24–48 h after NEC onset, and before and after the first re-feed. We assessed intestinal recovery in two ways: time to full enteral feeding (FEFt; below or equal/above group’s median) and development of post-NEC complications (recurrent NEC/post-NEC stricture). We determined whether the r int SO 2 , its range, and I-FABP u differed between groups. Results We included 27 preterm infants who survived NEC (Bell’s stage ≥ 2). Median FEFt was 14 [IQR: 12–23] days. Biomarkers only predicted intestinal recovery after the first re-feed. Mean r int SO 2  ≥ 53% combined with mean r int SO 2range  ≥ 50% predicted FEFt 
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-019-0634-y