Prevalence and risk factors for Felis catus gammaherpesvirus 1 detection in domestic cats in Italy

•A molecular survey for Felis catus gammaherpesvirus 1 (FcaGHV1) was conducted in Italy.•FcaGHV1 DNA was detected with virus-specific real-time PCR in 1% of 2659 feline blood samples tested.•Coinfections with feline immunodeficiency virus (FIV) were detected in one-third of the FcaGHV1 positive cats...

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Bibliographic Details
Published in:Veterinary microbiology 2019-11, Vol.238, p.108426-108426, Article 108426
Main Authors: Caringella, Francesca, Desario, Costantina, Lorusso, Eleonora, Pallante, Ivana, Furlanello, Tommaso, Lanave, Gianvito, Elia, Gabriella, Martella, Vito, Iatta, Roberta, Barrs, Vanessa R., Beatty, Julia, Buonavoglia, Canio, Decaro, Nicola
Format: Article
Language:English
Subjects:
Animals
Cat Diseases - diagnosis
Cat Diseases - epidemiology
Cat Diseases - virology
Cats
Coinfection - epidemiology
Coinfection - veterinary
Deoxyribonucleic acid
DNA
Epidemiology
Feline Acquired Immunodeficiency Syndrome - complications
Feline panleukopenia
Felis catus
Female
Gammaherpesvirinae - genetics
Gammaherpesvirus
Herpesviridae Infections - complications
Herpesviridae Infections - epidemiology
Herpesviridae Infections - veterinary
Immunodeficiency Virus, Feline - genetics
Italy - epidemiology
Male
Molecular Epidemiology
Molecular survey
Prevalence
Real-Time Polymerase Chain Reaction - veterinary
Risk analysis
Risk Factors
Sex Factors
Viruses
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Summary:•A molecular survey for Felis catus gammaherpesvirus 1 (FcaGHV1) was conducted in Italy.•FcaGHV1 DNA was detected with virus-specific real-time PCR in 1% of 2659 feline blood samples tested.•Coinfections with feline immunodeficiency virus (FIV) were detected in one-third of the FcaGHV1 positive cats.•FIV coinfection and male sex were the main risk factors associated with FcaGHV1 infection. Felis catus gammaherpesvirus 1 (FcaGHV1), a novel gammaherpesvirus of domestic cats identified in 2014, has been detected in different countries demonstrating a worldwide distribution. The aim of this study was to establish the prevalence of FcaGHV1 in Italy using a molecular epidemiological approach. FcaGHV1 DNA was detected with virus-specific real-time PCR in ≃1% of 2659 feline blood samples tested. Analysis of risk factors showed that being male and coinfection with feline immunodeficiency virus (FIV) increase the likelihood of FcaGHV1 detection. One-third of FcaGHV1-positive cats also tested positive for FIV provirus, whereas coinfections with feline panleukopenia virus were not demonstrated. Further studies are necessary to confirm the risk factors for FcaGHV1 detection and the pathobiology of the virus.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2019.108426