Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases

Various thyroid diseases are associated with autoimmunity. Major autoimmune thyroid diseases are Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). Thyrotropin receptor is an autoantigen in GD, and its immunogenicity has been examined. Immune-checkpoint inhibitor (ICI) is recently widely used fo...

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Bibliographic Details
Published in:Endocrine Journal 2019, Vol.66(10), pp.843-852
Main Authors: Inaba, Hidefumi, Ariyasu, Hiroyuki, Takeshima, Ken, Iwakura, Hiroshi, Akamizu, Takashi
Format: Article
Language:English
Subjects:
Animals
Autoantigens - immunology
Autoimmune diseases
Autoimmune Diseases - immunology
Autoimmunity
Autoimmunity - immunology
Clinical aspects
Graves Disease - immunology
Graves' disease
Hashimoto Disease - immunology
Hashimoto’s thyroiditis
HLA-DR Antigens - immunology
Humans
Immune checkpoint inhibitors
Immunogenicity
Immunoglobulin G - analysis
Immunoglobulin G - immunology
Immunoglobulin G4
Immunoglobulins
Immunotherapy - adverse effects
Receptors, Thyrotropin - antagonists & inhibitors
Receptors, Thyrotropin - immunology
Riedel’s thyroiditis
Th1 Cells - immunology
Th2 Cells - immunology
Thyroid diseases
Thyroid Diseases - immunology
Thyroid-stimulating hormone
Thyroiditis
Thyroiditis, Autoimmune - immunology
Tumors
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Summary:Various thyroid diseases are associated with autoimmunity. Major autoimmune thyroid diseases are Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). Thyrotropin receptor is an autoantigen in GD, and its immunogenicity has been examined. Immune-checkpoint inhibitor (ICI) is recently widely used for treatment of malignant tumors, but cases of thyroid diseases during ICI treatment have been increasing. Thyroid diseases during ICI therapy have been investigated in immunological and clinical aspects, and their Japanese official diagnostic guidelines were established. In addition, serum and tissue immunoglobulin-G4 levels have been examined in association with clinicopathological characteristics in GD, HT, and Riedel’s thyroiditis. We review these diseases associated with thyroid autoimmunity and comprehensively discuss their potential application in future research and therapeutic options.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ19-0234