Influence of pretreatment quality of life on prognosis in patients with urothelial carcinoma

Background We investigated the association between the pretreatment quality of life (QOL) and overall survival (OS) in patients with urothelial carcinoma (UC), as the influence of pretreatment QOL on prognosis remains unclear in patients with localized and metastatic UC. Methods Between June 2013 an...

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Bibliographic Details
Published in:International journal of clinical oncology 2020-02, Vol.25 (2), p.362-369
Main Authors: Suppanuntaroek, Sappaya, Hatakeyama, Shingo, Fujita, Naoki, Kubota, Yuka, Suzuki, Yuichiro, Okamoto, Teppei, Tobisawa, Yuki, Yoneyama, Tohru, Yamamoto, Hayato, Mori, Kazuyuki, Imai, Atsushi, Yoneyama, Takahiro, Hashimoto, Yasuhiro, Ohyama, Chikara
Format: Article
Language:English
Subjects:
Appetite loss
Bladder cancer
Cancer Research
Chemotherapy
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Metastasis
Oncology
Original Article
Patients
Prognosis
Quality of life
Regression analysis
Surgical Oncology
Urothelial carcinoma
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Summary:Background We investigated the association between the pretreatment quality of life (QOL) and overall survival (OS) in patients with urothelial carcinoma (UC), as the influence of pretreatment QOL on prognosis remains unclear in patients with localized and metastatic UC. Methods Between June 2013 and May 2019, we retrospectively investigated 205 patients with UC who received radical cystectomy or nephroureterectomy for non-metastatic UC (M0 group) or systemic chemotherapy for metastatic UC (M1 group). Patients answered the European Organization for the Research and Treatment of Cancer Quality-of-Life Questionnaire C30 (QLQ-C30) before the treatments. Patients were stratified into two groups: QOL high and low according to the optimal cutoff scores which were defined by receiver operating characteristic curve. Inverse probability of treatment weighting (IPTW)-adjusted multivariate Cox regression analyses were performed to investigate the clinical implication of pretreatment QOL score on OS in patients with UC. Results The number of patients in the M0 and M1 groups was 125 and 80, respectively. Optimal cutoff values in global, fatigue, pain, appetite loss, physical, and role scores were  33, > 33, > 16, 
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-019-01563-2