Myocardial Expression of SERCA2a and Structural and Functional Indices in Patients with Atrial Fibrillation

The study examined the relationships between SERCA2a expression in the myocardium and structural and functional indices in patients with atrial fibrillation. In uniform cohort of patients, this expression differed significantly but positively correlated with the size of the left atrium, end-systolic...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-10, Vol.167 (6), p.787-790
Main Authors: Kondrat’eva, D. S., Afanas’ev, S. A., Archakov, E. A., Tsapko, L. P., Batalov, R. E.
Format: Article
Language:English
Subjects:
Adult
Atrial fibrillation
Atrial Fibrillation - diagnostic imaging
Atrial Fibrillation - metabolism
Atrial Fibrillation - pathology
Atrial Fibrillation - physiopathology
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Biopsy
Blood Flow Velocity
Care and treatment
Cell Biology
Echocardiography
Experimental Methods for Clinical Practice
Female
Heart
Heart Atria - metabolism
Heart Atria - pathology
Heart Ventricles - physiopathology
Humans
Internal Medicine
Laboratory Medicine
Male
Middle Aged
Myocardium - metabolism
Myocardium - pathology
Pathology
Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
Ventricular Function, Left - physiology
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Summary:The study examined the relationships between SERCA2a expression in the myocardium and structural and functional indices in patients with atrial fibrillation. In uniform cohort of patients, this expression differed significantly but positively correlated with the size of the left atrium, end-systolic volume, and end-diastolic volume. In contrast, SERCA2a expression negatively correlated with early (peak E) and late (peak A) diastolic filling rates in left ventricle. SERCA2a expression was also associated with echocardiographic parameters reflecting structural and functional status of the heart in patients with persistent atrial fibrillation.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04623-9