Role of gut microbiota in liver disease

The gut microbiome is the natural intestinal inhabitant that has been recognized recently as a major player in the maintenance of human health and the pathophysiology of many diseases. Those commensals produce metabolites that have various effects on host biological functions. Therefore, alterations...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2020-01, Vol.318 (1), p.G84-G98
Main Authors: Albhaisi, Somaya A M, Bajaj, Jasmohan S, Sanyal, Arun J
Format: Article
Language:English
Subjects:
Animals
Bacteria - metabolism
Bacteria - pathogenicity
Disease Progression
Dysbiosis
Gastrointestinal Microbiome
Host-Pathogen Interactions
Humans
Intestines - microbiology
Liver - metabolism
Liver - pathology
Liver Diseases - metabolism
Liver Diseases - microbiology
Liver Diseases - pathology
Prognosis
Risk Factors
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Summary:The gut microbiome is the natural intestinal inhabitant that has been recognized recently as a major player in the maintenance of human health and the pathophysiology of many diseases. Those commensals produce metabolites that have various effects on host biological functions. Therefore, alterations in the normal composition or diversity of microbiome have been implicated in various diseases, including liver cirrhosis and nonalcoholic fatty liver disease. Moreover, accumulating evidence suggests that progression of dysbiosis can be associated with worsening of liver disease. Here, we review the possible roles for gut microbiota in the development, progression, and complication of liver disease.
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.00118.2019