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Expression dynamics of autophagy-related genes in the cattle tick Rhipicephalus microplus during embryonic development and under increasing larval starvation
Rhipicephalus microplus is a hematophagous ectoparasite that significantly affects parasitized cattle. As a one-host tick its entire life cycle consists of free-living and parasitic forms. Its extraordinary ability to survive during prolonged off-host periods has been related to the process of cytop...
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| Published in: | Experimental & applied acarology 2019-10, Vol.79 (2), p.255-266 |
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| cites | cdi_FETCH-LOGICAL-c375t-4bbd031fb0652cf0d7112c603c085914e0a6ebba52ffca1c7edf9caf41ef83d43 |
| container_end_page | 266 |
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| container_start_page | 255 |
| container_title | Experimental & applied acarology |
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| creator | González Castillo, Celia Ortuño Sahagún, Daniel Martínez Velázquez, Moisés |
| description | Rhipicephalus microplus
is a hematophagous ectoparasite that significantly affects parasitized cattle. As a one-host tick its entire life cycle consists of free-living and parasitic forms. Its extraordinary ability to survive during prolonged off-host periods has been related to the process of cytoplasmic degradation called autophagy. In order to deepen our understanding of this process during
R. microplus
non-parasitic stages, we determined the expression dynamics of a set of five autophagy-related genes (
ATG
genes) during embryonic development and over an increasing larval starvation period of 50 days. We found two apparent successive waves of
ATG
genes transcriptional activation, which paralleled key embryonic changes such as cellularization and organogenesis, as well as nutrient utilization. Moreover, during increasing larval starvation,
ATG
genes were up-regulated cyclically every 10–15 days. Taken together, our results suggest that autophagy is playing a major role in embryo development and energy metabolism during starvation in
R. microplus
. |
| doi_str_mv | 10.1007/s10493-019-00428-7 |
| format | article |
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is a hematophagous ectoparasite that significantly affects parasitized cattle. As a one-host tick its entire life cycle consists of free-living and parasitic forms. Its extraordinary ability to survive during prolonged off-host periods has been related to the process of cytoplasmic degradation called autophagy. In order to deepen our understanding of this process during
R. microplus
non-parasitic stages, we determined the expression dynamics of a set of five autophagy-related genes (
ATG
genes) during embryonic development and over an increasing larval starvation period of 50 days. We found two apparent successive waves of
ATG
genes transcriptional activation, which paralleled key embryonic changes such as cellularization and organogenesis, as well as nutrient utilization. Moreover, during increasing larval starvation,
ATG
genes were up-regulated cyclically every 10–15 days. Taken together, our results suggest that autophagy is playing a major role in embryo development and energy metabolism during starvation in
R. microplus
.</description><identifier>ISSN: 0168-8162</identifier><identifier>EISSN: 1572-9702</identifier><identifier>DOI: 10.1007/s10493-019-00428-7</identifier><identifier>PMID: 31659545</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animal Ecology ; Animal Genetics and Genomics ; Animal Systematics/Taxonomy/Biogeography ; Animals ; Arthropod Proteins - genetics ; Arthropod Proteins - metabolism ; Autophagy ; Autophagy - genetics ; Biomedical and Life Sciences ; Cattle ; Cattle - parasitology ; Ectoparasites ; Embryogenesis ; Embryonic Development - genetics ; Embryonic growth stage ; Embryos ; Energy metabolism ; Entomology ; Gene Expression ; Genes ; Larva - genetics ; Life cycles ; Life Sciences ; Mexico ; Nutrient utilization ; Organogenesis ; Phagocytosis ; Rhipicephalus - embryology ; Rhipicephalus - genetics ; Rhipicephalus - growth & development ; Rhipicephalus microplus ; Transcription activation</subject><ispartof>Experimental & applied acarology, 2019-10, Vol.79 (2), p.255-266</ispartof><rights>Springer Nature Switzerland AG 2019</rights><rights>Experimental and Applied Acarology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4bbd031fb0652cf0d7112c603c085914e0a6ebba52ffca1c7edf9caf41ef83d43</citedby><cites>FETCH-LOGICAL-c375t-4bbd031fb0652cf0d7112c603c085914e0a6ebba52ffca1c7edf9caf41ef83d43</cites><orcidid>0000-0002-8060-6832</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31659545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González Castillo, Celia</creatorcontrib><creatorcontrib>Ortuño Sahagún, Daniel</creatorcontrib><creatorcontrib>Martínez Velázquez, Moisés</creatorcontrib><title>Expression dynamics of autophagy-related genes in the cattle tick Rhipicephalus microplus during embryonic development and under increasing larval starvation</title><title>Experimental & applied acarology</title><addtitle>Exp Appl Acarol</addtitle><addtitle>Exp Appl Acarol</addtitle><description>Rhipicephalus microplus
is a hematophagous ectoparasite that significantly affects parasitized cattle. As a one-host tick its entire life cycle consists of free-living and parasitic forms. Its extraordinary ability to survive during prolonged off-host periods has been related to the process of cytoplasmic degradation called autophagy. In order to deepen our understanding of this process during
R. microplus
non-parasitic stages, we determined the expression dynamics of a set of five autophagy-related genes (
ATG
genes) during embryonic development and over an increasing larval starvation period of 50 days. We found two apparent successive waves of
ATG
genes transcriptional activation, which paralleled key embryonic changes such as cellularization and organogenesis, as well as nutrient utilization. Moreover, during increasing larval starvation,
ATG
genes were up-regulated cyclically every 10–15 days. Taken together, our results suggest that autophagy is playing a major role in embryo development and energy metabolism during starvation in
R. microplus
.</description><subject>Animal Ecology</subject><subject>Animal Genetics and Genomics</subject><subject>Animal Systematics/Taxonomy/Biogeography</subject><subject>Animals</subject><subject>Arthropod Proteins - genetics</subject><subject>Arthropod Proteins - metabolism</subject><subject>Autophagy</subject><subject>Autophagy - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Cattle</subject><subject>Cattle - parasitology</subject><subject>Ectoparasites</subject><subject>Embryogenesis</subject><subject>Embryonic Development - genetics</subject><subject>Embryonic growth stage</subject><subject>Embryos</subject><subject>Energy metabolism</subject><subject>Entomology</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Larva - genetics</subject><subject>Life cycles</subject><subject>Life Sciences</subject><subject>Mexico</subject><subject>Nutrient utilization</subject><subject>Organogenesis</subject><subject>Phagocytosis</subject><subject>Rhipicephalus - embryology</subject><subject>Rhipicephalus - genetics</subject><subject>Rhipicephalus - growth & development</subject><subject>Rhipicephalus microplus</subject><subject>Transcription activation</subject><issn>0168-8162</issn><issn>1572-9702</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQhy0EokvhBTggS1x6CYztOH-OqCoFqRISgnPk2ONdF8cJtlOxD8O74nQLSBw4jQ_ffJ6ZHyEvGbxhAO3bxKDuRQWsrwBq3lXtI7JjsuVV3wJ_THbAmq7qWMPPyLOUbgFAQiOfkjPBGtnLWu7Iz6sfS8SU3ByoOQY1OZ3obKla87wc1P5YRfQqo6F7DJioCzQfkGqVs0eanf5GPx_c4jQW2q-JFkGcl-1l1ujCnuI0xuMcnKYG79DPy4QhUxUMXYPBWIw6okob6lW8U56mvNVcRnpOnljlE754qOfk6_urL5cfqptP1x8v391UWrQyV_U4GhDMjmU7ri2YljGuGxAaOtmzGkE1OI5Kcmu1YrpFY3utbM3QdsLU4pxcnLxLnL-vmPIwuaTRexVwXtPABQPes0bwgr7-B72d1xjKdPdU18pObEJ-osoxUopohyW6ScXjwGDYwhtO4Q0lvOE-vKEtTa8e1Os4ofnT8jutAogTkJbttBj__v0f7S_PUKmz</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>González Castillo, Celia</creator><creator>Ortuño Sahagún, Daniel</creator><creator>Martínez Velázquez, Moisés</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8060-6832</orcidid></search><sort><creationdate>20191001</creationdate><title>Expression dynamics of autophagy-related genes in the cattle tick Rhipicephalus microplus during embryonic development and under increasing larval starvation</title><author>González Castillo, Celia ; Ortuño Sahagún, Daniel ; Martínez Velázquez, Moisés</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4bbd031fb0652cf0d7112c603c085914e0a6ebba52ffca1c7edf9caf41ef83d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal Ecology</topic><topic>Animal Genetics and Genomics</topic><topic>Animal Systematics/Taxonomy/Biogeography</topic><topic>Animals</topic><topic>Arthropod Proteins - genetics</topic><topic>Arthropod Proteins - metabolism</topic><topic>Autophagy</topic><topic>Autophagy - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Cattle</topic><topic>Cattle - parasitology</topic><topic>Ectoparasites</topic><topic>Embryogenesis</topic><topic>Embryonic Development - genetics</topic><topic>Embryonic growth stage</topic><topic>Embryos</topic><topic>Energy metabolism</topic><topic>Entomology</topic><topic>Gene Expression</topic><topic>Genes</topic><topic>Larva - genetics</topic><topic>Life cycles</topic><topic>Life Sciences</topic><topic>Mexico</topic><topic>Nutrient utilization</topic><topic>Organogenesis</topic><topic>Phagocytosis</topic><topic>Rhipicephalus - embryology</topic><topic>Rhipicephalus - genetics</topic><topic>Rhipicephalus - growth & development</topic><topic>Rhipicephalus microplus</topic><topic>Transcription activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González Castillo, Celia</creatorcontrib><creatorcontrib>Ortuño Sahagún, Daniel</creatorcontrib><creatorcontrib>Martínez Velázquez, Moisés</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental & applied acarology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González Castillo, Celia</au><au>Ortuño Sahagún, Daniel</au><au>Martínez Velázquez, Moisés</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression dynamics of autophagy-related genes in the cattle tick Rhipicephalus microplus during embryonic development and under increasing larval starvation</atitle><jtitle>Experimental & applied acarology</jtitle><stitle>Exp Appl Acarol</stitle><addtitle>Exp Appl Acarol</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>79</volume><issue>2</issue><spage>255</spage><epage>266</epage><pages>255-266</pages><issn>0168-8162</issn><eissn>1572-9702</eissn><abstract>Rhipicephalus microplus
is a hematophagous ectoparasite that significantly affects parasitized cattle. As a one-host tick its entire life cycle consists of free-living and parasitic forms. Its extraordinary ability to survive during prolonged off-host periods has been related to the process of cytoplasmic degradation called autophagy. In order to deepen our understanding of this process during
R. microplus
non-parasitic stages, we determined the expression dynamics of a set of five autophagy-related genes (
ATG
genes) during embryonic development and over an increasing larval starvation period of 50 days. We found two apparent successive waves of
ATG
genes transcriptional activation, which paralleled key embryonic changes such as cellularization and organogenesis, as well as nutrient utilization. Moreover, during increasing larval starvation,
ATG
genes were up-regulated cyclically every 10–15 days. Taken together, our results suggest that autophagy is playing a major role in embryo development and energy metabolism during starvation in
R. microplus
.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31659545</pmid><doi>10.1007/s10493-019-00428-7</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8060-6832</orcidid></addata></record> |
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| ispartof | Experimental & applied acarology, 2019-10, Vol.79 (2), p.255-266 |
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| subjects | Animal Ecology Animal Genetics and Genomics Animal Systematics/Taxonomy/Biogeography Animals Arthropod Proteins - genetics Arthropod Proteins - metabolism Autophagy Autophagy - genetics Biomedical and Life Sciences Cattle Cattle - parasitology Ectoparasites Embryogenesis Embryonic Development - genetics Embryonic growth stage Embryos Energy metabolism Entomology Gene Expression Genes Larva - genetics Life cycles Life Sciences Mexico Nutrient utilization Organogenesis Phagocytosis Rhipicephalus - embryology Rhipicephalus - genetics Rhipicephalus - growth & development Rhipicephalus microplus Transcription activation |
| title | Expression dynamics of autophagy-related genes in the cattle tick Rhipicephalus microplus during embryonic development and under increasing larval starvation |
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