Preoperative total cholesterol-lymphocyte score as a novel immunonutritional predictor of survival in gastric cancer

Purpose Immunonutritional status is a known prognostic correlate in the context of gastric cancer (GC). In the present study, we investigated the prognostic relevance of a lipid profile-based immunonutritional score in patients with GC. Methods Data pertaining to 224 patients with stage II and III G...

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Published in:Langenbeck's archives of surgery 2019-09, Vol.404 (6), p.743-752
Main Authors: Matsubara, Daiki, Shoda, Katsutoshi, Kubota, Takeshi, Kosuga, Toshiyuki, Konishi, Hirotaka, Shiozaki, Atsushi, Fujiwara, Hitoshi, Okamoto, Kazuma, Kudou, Michihiro, Arita, Tomohiro, Morimura, Ryo, Murayama, Yasutoshi, Ikoma, Hisashi, Kuriu, Yoshiaki, Nakanishi, Masayoshi, Otsuji, Eigo
Format: Article
Language:English
Subjects:
Abdominal Surgery
Cardiac Surgery
General Surgery
Medicine
Medicine & Public Health
Original Article
Thoracic Surgery
Traumatic Surgery
Vascular Surgery
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Summary:Purpose Immunonutritional status is a known prognostic correlate in the context of gastric cancer (GC). In the present study, we investigated the prognostic relevance of a lipid profile-based immunonutritional score in patients with GC. Methods Data pertaining to 224 patients with stage II and III GC who underwent curative gastrectomy were retrospectively analyzed. The total cholesterol-lymphocyte score (TL score) was defined as follows: patients with both low total cholesterol (TC) and total lymphocyte count were allocated a score of 2; patients with only one or none of these biochemical abnormalities were allocated a score of 1 or 0, respectively. Results Among the serum lipid indices, low TC was the strongest predictor of cancer-specific survival (CSS; p  = 0.001). On multivariate analysis, both low prognostic nutritional index (PNI) ( p  
ISSN:1435-2443
1435-2451
DOI:10.1007/s00423-019-01824-8