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Preoperative total cholesterol-lymphocyte score as a novel immunonutritional predictor of survival in gastric cancer
Purpose Immunonutritional status is a known prognostic correlate in the context of gastric cancer (GC). In the present study, we investigated the prognostic relevance of a lipid profile-based immunonutritional score in patients with GC. Methods Data pertaining to 224 patients with stage II and III G...
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| Published in: | Langenbeck's archives of surgery 2019-09, Vol.404 (6), p.743-752 |
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| creator | Matsubara, Daiki Shoda, Katsutoshi Kubota, Takeshi Kosuga, Toshiyuki Konishi, Hirotaka Shiozaki, Atsushi Fujiwara, Hitoshi Okamoto, Kazuma Kudou, Michihiro Arita, Tomohiro Morimura, Ryo Murayama, Yasutoshi Ikoma, Hisashi Kuriu, Yoshiaki Nakanishi, Masayoshi Otsuji, Eigo |
| description | Purpose
Immunonutritional status is a known prognostic correlate in the context of gastric cancer (GC). In the present study, we investigated the prognostic relevance of a lipid profile-based immunonutritional score in patients with GC.
Methods
Data pertaining to 224 patients with stage II and III GC who underwent curative gastrectomy were retrospectively analyzed. The total cholesterol-lymphocyte score (TL score) was defined as follows: patients with both low total cholesterol (TC) and total lymphocyte count were allocated a score of 2; patients with only one or none of these biochemical abnormalities were allocated a score of 1 or 0, respectively.
Results
Among the serum lipid indices, low TC was the strongest predictor of cancer-specific survival (CSS;
p
= 0.001). On multivariate analysis, both low prognostic nutritional index (PNI) (
p
|
| doi_str_mv | 10.1007/s00423-019-01824-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2310296020</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2310296020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-10c58cfa46b93fb557fe4476523a65e8d490d39b79c922dcdff04967e1be15a63</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoMo3l_AhWTppppr2yxFvIGgC12HND11MrRNTdKBeXujM87SRUjI-f4fzofQBSXXlJDqJhIiGC8IVfnUTBT1HjqmgsuCCUn3d2_Bj9BJjEtCSFkpcYiOOC2lysNjlN4C-AmCSW4FOPlkemwXvoeYIPi-6NfDtPB2nQBH6wNgE7HBo19Bj90wzKMf5xRccn7MySlA62zyAfsOxzms3Cr_uhF_mpgpi60ZLYQzdNCZPsL59j5FHw_373dPxcvr4_Pd7UthBeWpoMTK2nZGlI3iXSNl1YEQVSkZN6WEuhWKtFw1lbKKsda2XUeEKiugDVBpSn6Krja9U_Bfc15JDy5a6Hszgp-jZpwSpkrCSEbZBrXBxxig01NwgwlrTYn-sa03tnW2rX9t6zqHLrf9czNAu4v86c0A3wAxj8ZPCHrp55BNxf9qvwGHEY2E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2310296020</pqid></control><display><type>article</type><title>Preoperative total cholesterol-lymphocyte score as a novel immunonutritional predictor of survival in gastric cancer</title><source>Springer Nature</source><creator>Matsubara, Daiki ; Shoda, Katsutoshi ; Kubota, Takeshi ; Kosuga, Toshiyuki ; Konishi, Hirotaka ; Shiozaki, Atsushi ; Fujiwara, Hitoshi ; Okamoto, Kazuma ; Kudou, Michihiro ; Arita, Tomohiro ; Morimura, Ryo ; Murayama, Yasutoshi ; Ikoma, Hisashi ; Kuriu, Yoshiaki ; Nakanishi, Masayoshi ; Otsuji, Eigo</creator><creatorcontrib>Matsubara, Daiki ; Shoda, Katsutoshi ; Kubota, Takeshi ; Kosuga, Toshiyuki ; Konishi, Hirotaka ; Shiozaki, Atsushi ; Fujiwara, Hitoshi ; Okamoto, Kazuma ; Kudou, Michihiro ; Arita, Tomohiro ; Morimura, Ryo ; Murayama, Yasutoshi ; Ikoma, Hisashi ; Kuriu, Yoshiaki ; Nakanishi, Masayoshi ; Otsuji, Eigo</creatorcontrib><description>Purpose
Immunonutritional status is a known prognostic correlate in the context of gastric cancer (GC). In the present study, we investigated the prognostic relevance of a lipid profile-based immunonutritional score in patients with GC.
Methods
Data pertaining to 224 patients with stage II and III GC who underwent curative gastrectomy were retrospectively analyzed. The total cholesterol-lymphocyte score (TL score) was defined as follows: patients with both low total cholesterol (TC) and total lymphocyte count were allocated a score of 2; patients with only one or none of these biochemical abnormalities were allocated a score of 1 or 0, respectively.
Results
Among the serum lipid indices, low TC was the strongest predictor of cancer-specific survival (CSS;
p
= 0.001). On multivariate analysis, both low prognostic nutritional index (PNI) (
p
< 0.001) and high TL score (
p
= 0.003) were independent prognostic factors. PNI was significantly associated with peritoneal recurrence (
p
= 0.047), while TL score was significantly associated with locoregional and distant metastasis (
p
= 0.004 and
p
= 0.003, respectively).
Conclusions
TL score may facilitate risk stratification of patients based on CSS. TL score plus PNI may help predict the recurrence pattern in patients with stage II and III GC.</description><identifier>ISSN: 1435-2443</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-019-01824-8</identifier><identifier>PMID: 31659435</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdominal Surgery ; Cardiac Surgery ; General Surgery ; Medicine ; Medicine & Public Health ; Original Article ; Thoracic Surgery ; Traumatic Surgery ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2019-09, Vol.404 (6), p.743-752</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-10c58cfa46b93fb557fe4476523a65e8d490d39b79c922dcdff04967e1be15a63</citedby><cites>FETCH-LOGICAL-c413t-10c58cfa46b93fb557fe4476523a65e8d490d39b79c922dcdff04967e1be15a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31659435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsubara, Daiki</creatorcontrib><creatorcontrib>Shoda, Katsutoshi</creatorcontrib><creatorcontrib>Kubota, Takeshi</creatorcontrib><creatorcontrib>Kosuga, Toshiyuki</creatorcontrib><creatorcontrib>Konishi, Hirotaka</creatorcontrib><creatorcontrib>Shiozaki, Atsushi</creatorcontrib><creatorcontrib>Fujiwara, Hitoshi</creatorcontrib><creatorcontrib>Okamoto, Kazuma</creatorcontrib><creatorcontrib>Kudou, Michihiro</creatorcontrib><creatorcontrib>Arita, Tomohiro</creatorcontrib><creatorcontrib>Morimura, Ryo</creatorcontrib><creatorcontrib>Murayama, Yasutoshi</creatorcontrib><creatorcontrib>Ikoma, Hisashi</creatorcontrib><creatorcontrib>Kuriu, Yoshiaki</creatorcontrib><creatorcontrib>Nakanishi, Masayoshi</creatorcontrib><creatorcontrib>Otsuji, Eigo</creatorcontrib><title>Preoperative total cholesterol-lymphocyte score as a novel immunonutritional predictor of survival in gastric cancer</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Purpose
Immunonutritional status is a known prognostic correlate in the context of gastric cancer (GC). In the present study, we investigated the prognostic relevance of a lipid profile-based immunonutritional score in patients with GC.
Methods
Data pertaining to 224 patients with stage II and III GC who underwent curative gastrectomy were retrospectively analyzed. The total cholesterol-lymphocyte score (TL score) was defined as follows: patients with both low total cholesterol (TC) and total lymphocyte count were allocated a score of 2; patients with only one or none of these biochemical abnormalities were allocated a score of 1 or 0, respectively.
Results
Among the serum lipid indices, low TC was the strongest predictor of cancer-specific survival (CSS;
p
= 0.001). On multivariate analysis, both low prognostic nutritional index (PNI) (
p
< 0.001) and high TL score (
p
= 0.003) were independent prognostic factors. PNI was significantly associated with peritoneal recurrence (
p
= 0.047), while TL score was significantly associated with locoregional and distant metastasis (
p
= 0.004 and
p
= 0.003, respectively).
Conclusions
TL score may facilitate risk stratification of patients based on CSS. TL score plus PNI may help predict the recurrence pattern in patients with stage II and III GC.</description><subject>Abdominal Surgery</subject><subject>Cardiac Surgery</subject><subject>General Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Vascular Surgery</subject><issn>1435-2443</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMo3l_AhWTppppr2yxFvIGgC12HND11MrRNTdKBeXujM87SRUjI-f4fzofQBSXXlJDqJhIiGC8IVfnUTBT1HjqmgsuCCUn3d2_Bj9BJjEtCSFkpcYiOOC2lysNjlN4C-AmCSW4FOPlkemwXvoeYIPi-6NfDtPB2nQBH6wNgE7HBo19Bj90wzKMf5xRccn7MySlA62zyAfsOxzms3Cr_uhF_mpgpi60ZLYQzdNCZPsL59j5FHw_373dPxcvr4_Pd7UthBeWpoMTK2nZGlI3iXSNl1YEQVSkZN6WEuhWKtFw1lbKKsda2XUeEKiugDVBpSn6Krja9U_Bfc15JDy5a6Hszgp-jZpwSpkrCSEbZBrXBxxig01NwgwlrTYn-sa03tnW2rX9t6zqHLrf9czNAu4v86c0A3wAxj8ZPCHrp55BNxf9qvwGHEY2E</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Matsubara, Daiki</creator><creator>Shoda, Katsutoshi</creator><creator>Kubota, Takeshi</creator><creator>Kosuga, Toshiyuki</creator><creator>Konishi, Hirotaka</creator><creator>Shiozaki, Atsushi</creator><creator>Fujiwara, Hitoshi</creator><creator>Okamoto, Kazuma</creator><creator>Kudou, Michihiro</creator><creator>Arita, Tomohiro</creator><creator>Morimura, Ryo</creator><creator>Murayama, Yasutoshi</creator><creator>Ikoma, Hisashi</creator><creator>Kuriu, Yoshiaki</creator><creator>Nakanishi, Masayoshi</creator><creator>Otsuji, Eigo</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190901</creationdate><title>Preoperative total cholesterol-lymphocyte score as a novel immunonutritional predictor of survival in gastric cancer</title><author>Matsubara, Daiki ; Shoda, Katsutoshi ; Kubota, Takeshi ; Kosuga, Toshiyuki ; Konishi, Hirotaka ; Shiozaki, Atsushi ; Fujiwara, Hitoshi ; Okamoto, Kazuma ; Kudou, Michihiro ; Arita, Tomohiro ; Morimura, Ryo ; Murayama, Yasutoshi ; Ikoma, Hisashi ; Kuriu, Yoshiaki ; Nakanishi, Masayoshi ; Otsuji, Eigo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-10c58cfa46b93fb557fe4476523a65e8d490d39b79c922dcdff04967e1be15a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdominal Surgery</topic><topic>Cardiac Surgery</topic><topic>General Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsubara, Daiki</creatorcontrib><creatorcontrib>Shoda, Katsutoshi</creatorcontrib><creatorcontrib>Kubota, Takeshi</creatorcontrib><creatorcontrib>Kosuga, Toshiyuki</creatorcontrib><creatorcontrib>Konishi, Hirotaka</creatorcontrib><creatorcontrib>Shiozaki, Atsushi</creatorcontrib><creatorcontrib>Fujiwara, Hitoshi</creatorcontrib><creatorcontrib>Okamoto, Kazuma</creatorcontrib><creatorcontrib>Kudou, Michihiro</creatorcontrib><creatorcontrib>Arita, Tomohiro</creatorcontrib><creatorcontrib>Morimura, Ryo</creatorcontrib><creatorcontrib>Murayama, Yasutoshi</creatorcontrib><creatorcontrib>Ikoma, Hisashi</creatorcontrib><creatorcontrib>Kuriu, Yoshiaki</creatorcontrib><creatorcontrib>Nakanishi, Masayoshi</creatorcontrib><creatorcontrib>Otsuji, Eigo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsubara, Daiki</au><au>Shoda, Katsutoshi</au><au>Kubota, Takeshi</au><au>Kosuga, Toshiyuki</au><au>Konishi, Hirotaka</au><au>Shiozaki, Atsushi</au><au>Fujiwara, Hitoshi</au><au>Okamoto, Kazuma</au><au>Kudou, Michihiro</au><au>Arita, Tomohiro</au><au>Morimura, Ryo</au><au>Murayama, Yasutoshi</au><au>Ikoma, Hisashi</au><au>Kuriu, Yoshiaki</au><au>Nakanishi, Masayoshi</au><au>Otsuji, Eigo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative total cholesterol-lymphocyte score as a novel immunonutritional predictor of survival in gastric cancer</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>404</volume><issue>6</issue><spage>743</spage><epage>752</epage><pages>743-752</pages><issn>1435-2443</issn><eissn>1435-2451</eissn><abstract>Purpose
Immunonutritional status is a known prognostic correlate in the context of gastric cancer (GC). In the present study, we investigated the prognostic relevance of a lipid profile-based immunonutritional score in patients with GC.
Methods
Data pertaining to 224 patients with stage II and III GC who underwent curative gastrectomy were retrospectively analyzed. The total cholesterol-lymphocyte score (TL score) was defined as follows: patients with both low total cholesterol (TC) and total lymphocyte count were allocated a score of 2; patients with only one or none of these biochemical abnormalities were allocated a score of 1 or 0, respectively.
Results
Among the serum lipid indices, low TC was the strongest predictor of cancer-specific survival (CSS;
p
= 0.001). On multivariate analysis, both low prognostic nutritional index (PNI) (
p
< 0.001) and high TL score (
p
= 0.003) were independent prognostic factors. PNI was significantly associated with peritoneal recurrence (
p
= 0.047), while TL score was significantly associated with locoregional and distant metastasis (
p
= 0.004 and
p
= 0.003, respectively).
Conclusions
TL score may facilitate risk stratification of patients based on CSS. TL score plus PNI may help predict the recurrence pattern in patients with stage II and III GC.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31659435</pmid><doi>10.1007/s00423-019-01824-8</doi><tpages>10</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Abdominal Surgery Cardiac Surgery General Surgery Medicine Medicine & Public Health Original Article Thoracic Surgery Traumatic Surgery Vascular Surgery |
| title | Preoperative total cholesterol-lymphocyte score as a novel immunonutritional predictor of survival in gastric cancer |
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