Interleukin‐33 polymorphisms and serum concentrations in mycosis fungoides

Background Mycosis fungoides (MF) skin lesions are characterized by low‐grade inflammation, which may be sustained by proinflammatory cytokines as probably interleukin‐33 (IL‐33). We compared serum concentrations of IL‐33 and its receptor ST2 and the frequency of selected IL‐33 single nucleotide pol...

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Published in:International journal of dermatology 2020-03, Vol.59 (3), p.345-351
Main Authors: Rustowska‐Rogowska, Alicja, Gleń, Jolanta, Jarząbek, Tomasz, Rogowski, Wojciech, Rębała, Krzysztof, Zabłotna, Monika, Czajkowska, Katarzyna, Nowicki, Roman, Kowalczyk, Anna, Sokołowska‐Wojdyło, Małgorzata
Format: Article
Language:English
Subjects:
Control methods
Cytokines
Fungal infections
Inflammation
Interleukins
Mycosis
Mycosis fungoides
Nucleotides
Pruritus
Single-nucleotide polymorphism
Skin diseases
Skin lesions
St2 gene
Statistical analysis
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Summary:Background Mycosis fungoides (MF) skin lesions are characterized by low‐grade inflammation, which may be sustained by proinflammatory cytokines as probably interleukin‐33 (IL‐33). We compared serum concentrations of IL‐33 and its receptor ST2 and the frequency of selected IL‐33 single nucleotide polymorphisms (SNPs) between patients with MF and healthy controls. Methods In 88 patients with MF and 66 healthy controls, we analyzed SNPs in the 9894 and 11877 loci of the IL‐33 gene. Moreover, we measured serum concentrations of IL‐33 and its receptor ST2. Results There were no statistically significant differences in the frequencies of both IL‐33 SNPs between patients and controls. Compared with controls, patients with MF had similar IL‐33 serum concentrations (P = 0.71) but significantly increased ST2 concentrations (P 
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.14696