Protective effects of tenuifolin isolated from Polygala tenuifolia Willd roots on neuronal apoptosis and learning and memory deficits in mice with Alzheimer's disease

The roots of Polygala tenuifolia Willd have a long history of being used as a traditional Chinese medicine for the treatment of insomnia, forgetfulness, sorrow and depression. Tenuifolin (TEN) has been isolated from Polygala tenuifolia Willd roots, and this study was carried out to investigate the p...

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Bibliographic Details
Published in:Food & function 2019-11, Vol.10 (11), p.7453-7460
Main Authors: Wang, Lin, Jin, Gui Fang, Yu, He Han, Lu, Xiao Hua, Zou, Zhen Hua, Liang, Jia Qi, Yang, Hong
Format: Article
Language:English
Subjects:
Alzheimer Disease
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Andorra
Animal memory
Animals
Apoptosis
Apoptosis - drug effects
Chemical compounds
Diterpenes, Kaurane - chemistry
Diterpenes, Kaurane - pharmacology
Herbal medicine
Hippocampus
Insomnia
Learning
Male
Maze Learning
Medical treatment
Membrane potential
Membrane Potential, Mitochondrial
Memory - drug effects
Mice
Mice, Transgenic
Mitochondria
Molecular Structure
Neurodegenerative diseases
Neurons - drug effects
Peptide Fragments - metabolism
Pharmacology
Plant Roots - chemistry
Polygala - chemistry
Polygala tenuifolia
Presenilin 1
Roots
Sleep disorders
Spatial discrimination learning
Spatial memory
Traditional Chinese medicine
Transgenic mice
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Summary:The roots of Polygala tenuifolia Willd have a long history of being used as a traditional Chinese medicine for the treatment of insomnia, forgetfulness, sorrow and depression. Tenuifolin (TEN) has been isolated from Polygala tenuifolia Willd roots, and this study was carried out to investigate the potential beneficial effects of TEN on neuronal apoptosis and memory deficits in a mouse model of Alzheimer's disease (AD). TEN treatment reversed spatial learning and memory deficits, as well as neuronal apoptosis in hippocampal areas, in APP/PS1 transgenic AD mice. TEN treatment protected against Aβ25-35-induced apoptosis, loss of mitochondria-membrane potential, and activation of caspases-3 and -9 in SH-SY5Y cells. TEN has potential benefit in treating learning and memory deficits in APP/PS1 transgenic AD mice, and its effects may be associated with reversing AD pathology-induced neuronal apoptosis. These insights pave the way for further analysis of the potential of TEN as an AD therapeutic agent.
ISSN:2042-6496
2042-650X
DOI:10.1039/c9fo00994a