Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer

• Published in: Gene 2020-02, Vol.726, p.144132-144132, Article 144132
• Main Authors: Soleimani, Atena, Rahmani, Farzad, Ferns, Gordon A., Ryzhikov, Mikhail, Avan, Amir, Hassanian, Seyed Mahdi
• Format: Article
• Language: English
• Subjects: Animals; Apoptosis - physiology; Cell Proliferation - physiology; Colorectal cancer; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Humans; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; NF-kappa B - metabolism; NF-κB signaling; Pharmacological inhibitors; Quality of Life; Signal Transduction - physiology; Survival Rate; Tumorigenesis
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2019.144132

•Over-activation of the NF-κB pathway is a feature of CRC.•Suppression of the NF-κB signaling pathway is a potential therapeutic approach in the treatment of CRC.•This review summarizes the regulatory role of NF-κB signaling pathway in the pathogenesis of CRC. The NF-κB signaling pathway is a key regulator of CRC cell proliferation, apoptosis, angiogenesis, inflammation, metastasis, and drug resistance. Over-activation of the NF-κB pathway is a feature of colorectal cancer (CRC). While new combinatorial treatments have improved overall patient outcome; quality of life, cost of care, and patient survival rate have seen little improvement. Suppression of the NF-κB signaling pathway using biological or specific pharmacological inhibitors is a potential therapeutic approach in the treatment of colon cancer. This review summarizes the regulatory role of NF-κB signaling pathway in the pathogenesis of CRC for a better understanding and hence a better management of the disease.