Liver Transplantation for Non-hepatocellular Carcinoma Malignancy: A Single-Center Experience

Liver transplantation has become an effective treatment for selected patients with hepatocellular carcinoma with excellent outcomes. More recent reports have described improved outcomes in liver transplantation in a subset of patients with other malignancies like hilar cholangiocarcinoma, unresectab...

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Bibliographic Details
Published in:Transplantation proceedings 2019-12, Vol.51 (10), p.3355-3359
Main Authors: Mont`Alverne Pierre, Alessandra Maria, Veras, Camila Monteiro, Esmeraldo, Ticiana Mota, Schwermann, Maximilian Pinho, Studart e Neves, Marina Seixas, Bastos Pinho, José Eudes, Canito Brasil, Ivelise Regina
Format: Article
Language:English
Subjects:
Adult
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - surgery
Bile Ducts, Intrahepatic - pathology
Cholangiocarcinoma - surgery
Female
Hemangioendothelioma, Epithelioid - surgery
Hemangiosarcoma - surgery
Humans
Klatskin Tumor - surgery
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver Transplantation - methods
Male
Middle Aged
Neuroendocrine Tumors - surgery
Patient Selection
Retrospective Studies
Treatment Outcome
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Summary:Liver transplantation has become an effective treatment for selected patients with hepatocellular carcinoma with excellent outcomes. More recent reports have described improved outcomes in liver transplantation in a subset of patients with other malignancies like hilar cholangiocarcinoma, unresectable hepatic epithelioid hemangioendothelioma and hepatic metastasis from neuroendocrine tumors. However, hepatic angiosarcoma remains an absolute contraindication to liver transplantation because of the poor outcome. The present study aims to describe liver transplantation for non-hepatocellular carcinoma malignancy. A retrospective analysis of patients and review of the literature was performed. Results. A total of 5 patients with non-hepatocellular carcinoma malignancy on explants histopathologic findings were identified. They presented hepatic epithelioid hemangioendothelioma (1), neuroendocrine tumor (1), angiosarcoma (1) and cholangiocarcinoma (2). The mean length of follow-up was 22.8 ± 37.67 (range, 2-90 months). Of 5 patients evaluated, 3 patients remain with stable graft function. Future investigations are necessary to redefine the indications of liver transplantations to treat non-hepatocellular carcinoma malignancy and its limitation.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2019.09.001