To help aging populations, classify organismal senescence

Comprehensive disease classification and staging is required to address unmet needs of aging populations Globally, citizens exist for sustained periods in states of aging-related disease and multimorbidity. Given the urgent and unmet clinical, health care, workforce, and economic needs of aging popu...

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Published in:Science (American Association for the Advancement of Science) 2019-11, Vol.366 (6465), p.576-578
Main Authors: Calimport, Stuart R G, Bentley, Barry L, Stewart, Claire E, Pawelec, Graham, Scuteri, Angelo, Vinciguerra, Manlio, Slack, Cathy, Chen, Danica, Harries, Lorna W, Marchant, Gary, Fleming, G Alexander, Conboy, Michael, Antebi, Adam, Small, Gary W, Gil, Jesus, Lakatta, Edward G, Richardson, Arlan, Rosen, Clifford, Nikolich, Karoly, Wyss-Coray, Tony, Steinman, Lawrence, Montine, Thomas, de Magalhães, João Pedro, Campisi, Judith, Church, George
Format: Article
Language:English
Subjects:
Age related diseases
Aging
Atrophy - classification
Calcinosis - classification
Cellular Senescence
Classification
Damage prevention
Disease - classification
Health care
Health Policy
Human rights
Humans
International Classification of Diseases
Medical treatment
Metabolic Diseases - classification
Organs
Populations
Public health
Senescence
World Health Organization
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Summary:Comprehensive disease classification and staging is required to address unmet needs of aging populations Globally, citizens exist for sustained periods in states of aging-related disease and multimorbidity. Given the urgent and unmet clinical, health care, workforce, and economic needs of aging populations, we need interventions and programs that regenerate tissues and organs and prevent and reverse aging-related damage, disease, and frailty ( 1 ). In response to these challenges, the World Health Organization (WHO) has called for a comprehensive public-health response within an international legal framework based on human rights law ( 1 ). Yet for a clinical trial to be conducted, a disease to be diagnosed, intervention prescribed, and treatment administered; a corresponding disease classification code is needed, adopted nationally from the WHO International Classification of Diseases (ICD). Such classifications and staging are fundamental for health care governance among governments and intergovernmental bodies. We describe a systematic and comprehensive approach to the classification and staging of organismal senescence and aging-related diseases at the organ and tissue levels in order to guide policy and practice and enable appropriate interventions and clinical guidance, systems, resources, and infrastructure.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.aay7319