Development and optimization of flurbiprofen loaded microsponges; an in-vitro evaluation

• Published in: Pakistan journal of pharmaceutical sciences 2019-07, Vol.32 (4(Supplementary)), p.1773-1779
• Main Authors: Qureshi, Sundus, Zaman, Muhammad, Mahmood, Asif, Shah, Shahid, Amjad, Muhammad Wahab, Shaheryar, Zaib Ali, Sarfraz, Rai Muhammad, Khan, Sajid Mahmood, Raja, Maria Abdul Ghafoor
• Format: Article
• Language: English
• Subjects: Analysis; Delayed-Action Preparations - chemistry; Drug Compounding - methods; Drug Delivery Systems - methods; Electron microscopy; Flurbiprofen; Flurbiprofen - chemistry; Particle Size
• ISSN: 1011-601X

Current study was designed with the aim to employ quasi emulsification, and double emulsification techniques for the development of Flurbiprofen (FLB) loaded micro sponges, followed by their physicochemical evaluation. FTIR interpretations exhibited compatibility of ingredients, while crystallographic analysis revealed crystalline nature of pure drug, which was masked upon incorporation into microsponges. Optical microscope and SEM have exposed spherical and spongy surfaces of prepared micro sponges. Micromeritics suggested that the flow properties are excellent and microsponges have remarkable drug entrapment efficiency (98.55±0.08%). In-vitro dissolution studies demonstrated good control over release of FLB until 8th h from the prepared microsponges. However, a difference in cumulated amount of released drug was noticed i.e. EC based formulation has released about 99.3±0.10%, while XG facilitated EC based formulations offered 92.7±2.1% release of the drug. Zeta potential indicated access of negative charge while zeta sizer has described the range of the particle size between 2.6 to 3.5μm. Conclusively the results have advocated the suitability of selected ingredients for incorporation of FLB into microsponges for its sustained delivery.