Detection of inflammation from finger temperature profile in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory tissue disease that leads to cartilage, bone, and periarticular tissue damage. This study aimed to investigate whether the use of infrared thermography and measurement of temperature profiles along the hand fingers could detect the inflammation and...

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Bibliographic Details
Published in:Medical & biological engineering & computing 2019-12, Vol.57 (12), p.2629-2639
Main Authors: Pauk, J., Ihnatouski, M., Wasilewska, A.
Format: Article
Language:English
Subjects:
Arthritis
Arthritis, Rheumatoid - physiopathology
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Body Temperature - physiology
Cartilage
Case-Control Studies
Cold Temperature
Computer Applications
Cooling
Cooling curves
Diagnostic systems
Female
Finger
Fingers
Fingers - physiopathology
Human Physiology
Humans
Imaging
Inflammation
Inflammation - physiopathology
Infrared cameras
Infrared imaging
Male
Middle Aged
Original Article
Radiology
Rheumatoid arthritis
Standard deviation
Temperature
Temperature profiles
Thermography
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Summary:Rheumatoid arthritis (RA) is a chronic inflammatory tissue disease that leads to cartilage, bone, and periarticular tissue damage. This study aimed to investigate whether the use of infrared thermography and measurement of temperature profiles along the hand fingers could detect the inflammation and improve the diagnostic accuracy of the cold provocation test (0 °C for 5 s) and rewarming test (23 °C for180 s) in RA patients. Thirty RA patients (mean age = 49.5 years, standard deviation = 13.0 years) and 22 controls (mean age = 49.8 years, standard deviation = 7.5 years) were studied. Outcomes were the minimal and maximal: baseline temperature ( T1 ), the temperature post-cooling ( T2 ), the temperature post-rewarming ( T3 ), and the Tmax-Tmin along the axis of each finger. The statistical significance was observed for the thumb, index finger, middle finger, and ring finger post-cooling and post-rewarming. Receiver operating characteristics (ROC) analysis to distinguish between the two groups revealed that for the thumb, index finger, middle finger, and ring finger, the area under the ROC curve was statistically significantly ( p < 0.05) post-cooling. The cold provocation test used in this study discriminates between RA patients and controls and detects an inflammation in RA patients by the measurement of temperature profiles along the fingers using an infrared camera. Graphical abstract
ISSN:0140-0118
1741-0444
DOI:10.1007/s11517-019-02055-1