Arterial Stiffness Gradient, Systemic Reflection Coefficient, and Pulsatile Pressure Wave Transmission in Essential Hypertension

Arterial stiffness and impedance gradients are known to influence pressure wave propagation and macrovascular-microvascular interactions. We studied the association between the carotid-femoral arterial stiffness gradient and the systemic reflection coefficient (N=393); of this population, 246 also u...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2019-12, Vol.74 (6), p.1366-1372
Main Authors: London, Gerard M., Pannier, Bruno, Safar, Michel E.
Format: Article
Language:English
Subjects:
Blood Flow Velocity - physiology
Blood Pressure Determination - methods
Carotid Arteries
Case-Control Studies
Essential Hypertension - physiopathology
Female
Femoral Artery
Hemodynamics - physiology
Humans
Male
Middle Aged
Multivariate Analysis
Pulsatile Flow - physiology
Pulse Wave Analysis - methods
Reference Values
Regression Analysis
Vascular Resistance - physiology
Vascular Stiffness - physiology
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Summary:Arterial stiffness and impedance gradients are known to influence pressure wave propagation and macrovascular-microvascular interactions. We studied the association between the carotid-femoral arterial stiffness gradient and the systemic reflection coefficient (N=393); of this population, 246 also underwent assessment of forward/backward pressure wave propagation and microvascular pulsatile pressure transmission (MPPT). Hemodynamic parameters were measured noninvasively. From peripheral vascular resistance and characteristic impedance, we estimated the systemic reflection coefficient and MPPT on peripheral and cardiac microcirculation in age-matched, sex-matched and body mass index-matched individuals with (n=147) or without (n=98) hypertension. The arterial stiffness gradient, systemic reflection coefficient, and correlations between the arterial stiffness gradient and age or blood pressure were similar in both populations. MPPT was higher in hypertension (P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.119.13387