Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes

Asthma is a common disease in paediatrics and adults with a significant morbidity, mortality, and financial burden worldwide. Asthma is now recognized as a heterogeneous disease and emerging clinical and laboratory research has elucidated understanding of asthma’s underlying immunology. The future o...

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Bibliographic Details
Published in:Paediatric respiratory reviews 2020-11, Vol.36, p.118-127
Main Authors: Gans, Melissa D., Gavrilova, Tatyana
Format: Article
Language:English
Subjects:
Asthma
Biomarkers
Immunology
Pathophysiology
Phenotypes
Review
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Summary:Asthma is a common disease in paediatrics and adults with a significant morbidity, mortality, and financial burden worldwide. Asthma is now recognized as a heterogeneous disease and emerging clinical and laboratory research has elucidated understanding of asthma’s underlying immunology. The future of asthma is classifying asthma by endotype through connecting discernible characteristics with immunological mechanisms. This comprehensive review of the immunology of asthma details the currently known pathophysiology and clinical practice biomarkers in addition to forefront biologic and targeted therapies for all of the asthma endotypes. By understanding the immunology of asthma, practitioners will be able to diagnose patients by asthma endotype and provide personalized, biomarker-driven treatments to effectively control patients’ asthma.
ISSN:1526-0542
1526-0550
DOI:10.1016/j.prrv.2019.08.002