Aquaporins in the kidney: physiology and pathophysiology

The kidney is the central organ involved in maintaining water and sodium balance. In human kidneys, nine aquaporins (AQPs), including AQP1-8 and AQP11, have been found and are differentially expressed along the renal tubules and collecting ducts with distinct and critical roles in the regulation of...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2020-01, Vol.318 (1), p.F193-F203
Main Authors: Su, Wen, Cao, Rong, Zhang, Xiao-Yan, Guan, Youfei
Format: Article
Language:English
Subjects:
Animals
Aquaporins - metabolism
Homeostasis - physiology
Humans
Kidney - metabolism
Kidney Diseases - metabolism
Water-Electrolyte Balance - physiology
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Summary:The kidney is the central organ involved in maintaining water and sodium balance. In human kidneys, nine aquaporins (AQPs), including AQP1-8 and AQP11, have been found and are differentially expressed along the renal tubules and collecting ducts with distinct and critical roles in the regulation of body water homeostasis and urine concentration. Dysfunction and dysregulation of these AQPs result in various water balance disorders. This review summarizes current understanding of physiological and pathophysiological roles of AQPs in the kidney, with a focus on recent progress on AQP2 regulation by the nuclear receptor transcriptional factors. This review also provides an overview of AQPs as clinical biomarkers and therapeutic targets for renal diseases.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00304.2019