Vascular endothelial growth factor C/A 2578 gene polymorphism and umbilical artery Doppler in preeclamptic women

• Published in: Pregnancy hypertension 2019-10, Vol.18, p.173-178
• Main Authors: Mowad, Hanan H., Abougabal, Khadiga M., Fahim, Ashraf S., Shehata, Nesreen A.A., Ali, Hamada A.A., Nasser, Mona Z.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Blood Flow Velocity; Case-Control Studies; Egypt; Female; Genetic Predisposition to Disease; Genetic preeclampsia; Humans; Polymorphism; Polymorphism, Genetic; Pre-Eclampsia - genetics; Pre-Eclampsia - physiopathology; Pregnancy; Pulsatile Flow; Pulsatility index; Severity of Illness Index; Ultrasonography, Doppler; Umbilical Arteries - diagnostic imaging; Umbilical Arteries - physiopathology; Umbilical artery; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor C; Whites; Young Adult
• ISSN: 2210-7789; 2210-7797
• DOI: 10.1016/j.preghy.2019.09.016

•VEGF 2578C/A polymorphism was not related to preeclampsia in studied groups.•Severe cases of preeclampsia showed a relation between CA and CC genotypes and pulsatility index of the umbilical artery.•Progression to severe cases of PE is related to modifications in VEGF gene polymorphisms. Preeclampsia is strongly associated with placental hypoperfusion. Genetic factors have an impact on the pathogenesis of preeclampsia. The aim is to assess the association of Vascular Endothelial Growth Factor (C2578A) gene polymorphism with the occurrence and severity of preeclampsia and the umbilical artery Doppler changes among preeclamptic women. This case-control study was conducted in clinical and Chemical pathology and Obstetrics departments in Beni- Suef University, Egypt. Two hundred and ninety pregnant women above 20 weeks gestational age until delivery were divided into 2 main groups. The patient group included 145 preeclamptic women who were further sub grouped according to the severity of preeclampsia into 82 severe and 63 mild cases. Control group included 145 normotensive pregnant women. Our primary outcome was detection of VEGF C 2578 A gene mutations by a polymerase chain reaction. A secondary outcome was Doppler changes in the pulsatility index of the umbilical artery compared with VEGF genotypes. Our study showed that VEGF C 2578 A genotype and alleles frequencies were not related to the occurrence of preeclampsia (p-value 0.513 and 0.549, respectively), odds ratio (95%CI) 1.154 (0.724–1.848). Mild preeclamptic cases showed no significance comparing VEGF genotypes studied and pulsatility index of the umbilical artery. However, severe cases showed p-value