Acacetin Alleviates Hepatitis Following Renal Ischemia-Reperfusion in Male Balb/C Mice by Antioxidants Regulation and Inflammatory Markers Suppression

• Published in: Journal of investigative surgery 2021-05, Vol.34 (5), p.495-503
• Main Authors: Jalili, Cyrus, Akhshi, Nasim, Raissi, Farshid, Shiravi, Abdolhosein, Alvani, Alvand, Vaezi, Gholamhasan, Nedaei, Seyed Ershad, Ghanbari, Ali
• Format: Article
• Language: English
• Subjects: Acacetin; Animals; Antioxidants - therapeutic use; Flavones; Hepatitis; Ischemia; liver failure; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; physiopathology; renal ischemia/reperfusion; Reperfusion; Reperfusion Injury - drug therapy
• ISSN: 0894-1939; 1521-0553
• DOI: 10.1080/08941939.2019.1656309

Ischemia-reperfusion (Isc/Rep) incidence can damage kidneys and long-distance organs such as the liver. Due to the increasing use of herbs in medicine, this study was designed to assess the effects of Acacetin (ACA) on pathophysiology of liver following renal Isc/Rep induction. Methods: 84 male Balb/C mice were divided into 12 groups including control, control + ACAs groups (0.01% DMSO or 50, 25, 10 mg/kg of ACA.) sham group (a period of 60 min laparotomy with 0.01% DMSO treatment) sham + ACAs groups (0.01% DMSO + 50, 25, 10 mg/kg of ACA) Isc/Rep treatment groups (laparotomy and bilateralrenal occlusion for 60 min with/without administration of 50, 25, 10 mg/kg ACA). All experimental groups were treated intraperitoneally daily for 4 consecutive days. The values of quantitative histology, Total Antioxidant Capacity (TAC), Nitric oxide (NO), TNFα, IL1β, and the serum levels of hepatic enzymes were evaluated. Results: In the Isc/Rep and Isc/Rep + ACA (10 mg/kg) groups, there were a significant decrease in the level of albumin and TAC, while the other evaluated parameters were significantly increased (p