Relationship between interictal epileptiform discharges under medetomidine sedation and clinical seizures in canine idiopathic epilepsy

BackgroundElectroencephalography (EEG) is required for the diagnosis of canine idiopathic epilepsy as a highest confidence level of diagnosis by the International Veterinary Epilepsy Task Force; however, EEG is seldom used and a standardised assessment method has not been reported.MethodsInterictal...

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Bibliographic Details
Published in:Veterinary record 2020-07, Vol.187 (2), p.67-67
Main Authors: Utsugi, Shinichi, Saito, Miyoko, Sato, Toshikazu, Kunimi, Maki
Format: Article
Language:English
Subjects:
Age
Anesthesia
Animals
Blood
canine
Case-Control Studies
Convulsions & seizures
Dog Diseases - physiopathology
Dogs
Drug dosages
Electrocardiography
Electrodes
Electroencephalography
Electroencephalography - methods
Electroencephalography - veterinary
Epilepsy
Epilepsy - physiopathology
Epilepsy - veterinary
epileptiform discharge frequency
Female
Hypnotics and Sedatives - administration & dosage
Male
Medetomidine - administration & dosage
Metabolism
Seizures - physiopathology
Seizures - veterinary
severity of seizure
Sleep
Urinalysis
Veterinary medicine
visual analysis of EEG
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Summary:BackgroundElectroencephalography (EEG) is required for the diagnosis of canine idiopathic epilepsy as a highest confidence level of diagnosis by the International Veterinary Epilepsy Task Force; however, EEG is seldom used and a standardised assessment method has not been reported.MethodsInterictal EEG was performed under medetomidine sedation in dogs with idiopathic epilepsy and in control dogs. Epileptiform discharge (ED) frequency was compared between dogs with more severe and less severe seizures during one month before EEG and control dogs.ResultsAll 10 dogs with more severe seizures had ED, as had 7 of 11 with less severe seizures. All epileptic dogs without ED had good long-term outcomes. ED frequency (number of ED per five minutes) was significantly higher in dogs with more severe (median, 4.5) than with less severe seizure (median, 0.46) and in the control dogs (median, 0.15). An ED frequency greater than 0.8 was considered to indicate epilepsy.ConclusionInterictal EEG in a light sleep state under medetomidine sedation had a high detection rate of ED, and ED frequency had a positive correlation with the recent severity of epileptic seizures. This allows interictal EEG recordings to be used as a simplified and objective test that may help to diagnose epilepsy and to assess the recent severity of the disease in dogs.
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.104947