18F-PSMA 1007 Uptake in Brain Metastases From Breast Cancer

ABSTRACTA 64-year-old woman with metastatic breast cancer on follow-up had suspicious recurrent brain metastases. She underwent F-FDG PET/CT, F-PSMA 1007 brain PET/CT, and brain MRI. F-PSMA 1007 showed intense tracer localization in the suspected recurrent brain metastasis in right parietal lobe and...

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Bibliographic Details
Published in:Clinical nuclear medicine 2020-02, Vol.45 (2), p.e77-e79
Main Authors: Marafi, Fahad, Sasikumar, Arun, Alfeeli, Mahmoud, Fathallah, Wael
Format: Article
Language:English
Subjects:
Biological Transport
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - metabolism
Brain Neoplasms - secondary
Breast Neoplasms - pathology
Female
Humans
Middle Aged
Niacinamide - analogs & derivatives
Niacinamide - metabolism
Oligopeptides - metabolism
Positron Emission Tomography Computed Tomography
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Summary:ABSTRACTA 64-year-old woman with metastatic breast cancer on follow-up had suspicious recurrent brain metastases. She underwent F-FDG PET/CT, F-PSMA 1007 brain PET/CT, and brain MRI. F-PSMA 1007 showed intense tracer localization in the suspected recurrent brain metastasis in right parietal lobe and also picked up 2 more metastatic brain lesions, which had concurrent findings of metastasis in subsequent MRI. Our case highlights the feasibility of F-PSMA 1007 PET/CT imaging of brain metastases from nonprostate cancers. It may be used as surrogate imaging tracer for potential theranostic application using alpha or beta emitters considering its similarity to PSMA-617.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000002821