Mechanisms of Antiphospholipid Syndrome Induction: Role of NKT Cells

The review discusses the mechanisms of participation of natural killer T cells (NKT cells) in the induction of antiphospholipid antibodies (APA) that play a major pathogenetic role in the formation of antiphospholipid syndrome (APS), summarizes the data on APS pathogenesis, and presents modern conce...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2019-09, Vol.84 (9), p.992-1007
Main Author: Shirshev, S. V.
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Anticoagulants
Antigens
Antiphospholipid antibodies
Antiphospholipid syndrome
Apolipoproteins
Autoimmune diseases
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cytokines
Dendritic cells
Development and progression
Diagnosis
Genetic aspects
Glycoproteins
Influence
Killer cells
Kinases
Life Sciences
Ligands
Low density lipoprotein receptors
Lymphocytes
Lymphocytes T
Microbiology
Natural killer cells
Pathogenesis
Proteins
Review
T cell receptors
Thrombosis
Thymus gland
Tumor necrosis factor-TNF
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Description
Summary:The review discusses the mechanisms of participation of natural killer T cells (NKT cells) in the induction of antiphospholipid antibodies (APA) that play a major pathogenetic role in the formation of antiphospholipid syndrome (APS), summarizes the data on APS pathogenesis, and presents modern concepts on the antibody formation involving follicular helper type II NK cells.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297919090025