Design of polymeric nanocapsules to improve their lympho-targeting capacity

To design lympho-targeted nanocarriers with the capacity to enhance the activity of associated drugs/antigens whose target is within the lymphatic system. : Inulin (INU)-based nanocapsules (NCs), negatively charged and positively charged chitosan NCs were prepared by the solvent displacement techniq...

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Published in:Nanomedicine (London, England) England), 2019-12, Vol.14 (23), p.3013-3033
Main Authors: Crecente-Campo, José, Virgilio, Tommaso, Morone, Diego, Calviño-Sampedro, Cristina, Fernández-Mariño, Iago, Olivera, Ana, Varela-Calvino, Rubén, González, Santiago F, Alonso, María J
Format: Article
Language:English
Subjects:
Antigens
Aqueous solutions
Brownian motion
chitosan
dendritic cells
Ethanol
inulin
lymph nodes
Morphology
nanocapsules
Nanoparticles
Particle size
Pharmaceutical industry
Scanning electron microscopy
Sodium
targeting
Transmission electron microscopy
two-photon microscopy
Vaccines
Vitamin E
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Summary:To design lympho-targeted nanocarriers with the capacity to enhance the activity of associated drugs/antigens whose target is within the lymphatic system. : Inulin (INU)-based nanocapsules (NCs), negatively charged and positively charged chitosan NCs were prepared by the solvent displacement techniques. The NCs were produced in two sizes: small (70 nm) and medium (170–250 nm). results indicated that small NCs interacted more efficiently with dendritic cells than the larger ones. The study of the NCs biodistribution in mice, using 3D reconstruction of the popliteal lymph node, showed that small INU NCs have the greatest access and uniform accumulation in different subsets of resident immune cells. Small and negatively charged INU NCs have a potential as lympho-targeted antigen/drug nanocarriers.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2019-0206