Multicenter study of serotype distribution of Streptococcus pneumoniae nasopharyngeal isolates from healthy children in the Russian Federation after introduction of PCV13 into the National Vaccination Calendar

Russia introduced PCV13 in 2014. We studied the serotype composition of S. pneumoniae isolated from the nasopharynx of healthy children younger than 6 years in St. Petersburg, Smolensk, Perm, Krasnoyarsk, Khanty-Mansiysk and Khabarovsk, between 2016 and 2018. 2.4% of children had completed a 3-dose...

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Published in:Diagnostic microbiology and infectious disease 2020-01, Vol.96 (1), p.114914-114914, Article 114914
Main Authors: Sidorenko, Sergey, Rennert, Wolfgang, Lobzin, Yuri, Briko, Nikolay, Kozlov, Roman, Namazova-Baranova, Leila, Tsvetkova, Irina, Ageevets, Vladimir, Nikitina, Ekaterina, Ardysheva, Anastasia, Bikmieva, Alina, Bolgarova, Ekaterina, Volkova, Marina, Verentsova, Irina, Girina, Asiya, Gordeeva, Natalia, Demko, Irina, Dushchenko, Anna, Evseeva, Galina, Zharkova, Ludmila, Yelistratova, Tatyana, Zakharova, Julia, Ivakhnishina, Natalia, Zubova, Elena, Kalinogorskaya, Olga, Klimashina, Alla, Kozeeva, Tatiana, Kraposhina, Angelina, Krechikova, Olga, Mamaeva, Marina, Nagovitsyna, Elena, Protasova, Irina, Semerikov, Vadislav, Sokolova, Natalia, Soloveva, Irina, Strelnikova, Natalia, Telepneva, Regina, Feldblium, Irina, Kholodok, Galina, Chagaryan, Aida, Sheglinkova, Nadezhda
Format: Article
Language:English
Subjects:
Carrier State - epidemiology
Carrier State - microbiology
Child
Child, Preschool
Healthy Volunteers
Humans
Immunization Programs
Infant
Infant, Newborn
Nasopharynx - microbiology
PCV13
Pneumococcal Infections - epidemiology
Pneumococcal Infections - prevention & control
Pneumococcal serotypes
Pneumococcal Vaccines - administration & dosage
Post-vaccination serotype composition
Prevalence
Russia - epidemiology
Serogroup
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - genetics
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Summary:Russia introduced PCV13 in 2014. We studied the serotype composition of S. pneumoniae isolated from the nasopharynx of healthy children younger than 6 years in St. Petersburg, Smolensk, Perm, Krasnoyarsk, Khanty-Mansiysk and Khabarovsk, between 2016 and 2018. 2.4% of children had completed a 3-dose course of PCV13, while 25.6% had received 1 or 2 doses. Pneumococcal DNA detection by PCR demonstrated S. pneumoniae in 37.2% of samples with regional variation between sites (27.3 to 56.9%). There was little difference between vaccinated, partially vaccinated and un-vaccinated children. Children who had received at least 1 dose of PCV13 had lower carriage rates of vaccine serotypes than their unvaccinated peers (49.9 vs. 61.4%; p 
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2019.114914