Postprandial regulation of prouroguanylin in humans of a healthy weight and those who are overweight or with obesity

•Mixed macronutrient meals high in fat or carbohydrates cause a delayed increase in prourguanylin concentrations.•Fasting concentrations of prouroguanylin are supressed in those who are overweight/ with obesity.•People who are overweight /with obesity remain sensitive to the effects of meals on prou...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2020-01, Vol.123, p.170179-170179, Article 170179
Main Authors: Patterson, Michael, Ward, Hannah, Halvai, Delaram, Holm Nilsen, Heidi Anett, Reeves, Sue
Format: Article
Language:English
Subjects:
Adult
Diet, High-Fat
Dietary Carbohydrates - administration & dosage
Female
Food control
Gastrointestinal tract
Humans
Male
Obesity
Obesity - blood
Postprandial Period
Protein Precursors - blood
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Summary:•Mixed macronutrient meals high in fat or carbohydrates cause a delayed increase in prourguanylin concentrations.•Fasting concentrations of prouroguanylin are supressed in those who are overweight/ with obesity.•People who are overweight /with obesity remain sensitive to the effects of meals on prouroguanylin. Uroguanylin is a peptide gut hormone proposed to have a role in signalling post meal satiety. Uroguanylin circulates as its pro-hormone, prouroguanylin. There has been limited investigation of the regulation of prouroguanylin by food; therefore we investigated prouroguanylin regulation following meals. In separate experiments we investigated the effects of high calorie (1451 kcal) and medium calorie (725 kcal), high fat meals, on plasma prouroguanylin concentrations. We then examined the effect of a 722.5 kcal high carbohydrate breakfast on prouroguanylin concentrations, comparing the response in healthy weight adults versus those who are overweight/ with obesity. The 1451 kcal meal increased prouroguanylin concentrations, versus fasting at 60 (P 
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2019.170179