Association of Genetic Ancestry With DNA Methylation Changes in Prostate Cancer Disparity

Background: We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. Materials and Methods: Pyrosequencing and anc...

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Bibliographic Details
Published in:Anticancer research 2019-11, Vol.39 (11), p.5861-5866
Main Authors: APPREY, VICTOR, WANG, SONGPING, TANG, WEI, KITTLES, RICK A., SOUTHERLAND, WILLIAM M., ITTMANN, MICHAEL, KWABI-ADDO, BERNARD
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
DNA methylation
Ethnic factors
Population studies
Prostate cancer
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Summary:Background: We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. Materials and Methods: Pyrosequencing and ancestry informative markers were used for DNA methylation and genetic ancestry testing, respectively. Results: Using Spearman rho rank correlation test, the data demonstrated significant (p
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13790