The effects of hypogonadism on quality of life in survivors of germ cell tumors treated with surgery alone versus surgery plus platinum-based chemotherapy

Background It is important to assess the prevalence of hypogonadism and to identify the correlation between hypogonadism and cancer treatment with quality of life (QoL) in germ cell tumor (GCT) survivors. Methods This is a single-center, non-randomized, prospective observational study in GCT survivo...

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Bibliographic Details
Published in:Supportive care in cancer 2020-07, Vol.28 (7), p.3165-3170
Main Authors: Khanal, N., Ahmed, S. S., Kalra, M., Miller, T. J., Brames, M. J., Stump, T. E., Monahan, P., Hanna, N. H., Einhorn, Lawrence H.
Format: Article
Language:English
Subjects:
Cancer surgery
Chemotherapy
Clinical outcomes
Medicine
Medicine & Public Health
Nursing
Nursing Research
Oncology
Original Article
Pain Medicine
Palliative care
Quality of life
Rehabilitation Medicine
Survivor
Testosterone
Tumors
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Summary:Background It is important to assess the prevalence of hypogonadism and to identify the correlation between hypogonadism and cancer treatment with quality of life (QoL) in germ cell tumor (GCT) survivors. Methods This is a single-center, non-randomized, prospective observational study in GCT survivors 18–50 years of age previously treated with surgery and chemotherapy (S+C) or surgery alone (S). Patients completed a validated QoL questionnaire at baseline, 3, and 6 months. Patients received supplemental testosterone as clinically indicated. Mean QoL scores were compared between two treatment groups (S+C vs. S) and within each group between survivors with hypogonadism (serum testosterone level
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-019-05117-0