Retina thickness as a marker of neurodegeneration in prodromal lewy body disease

• Published in: Movement disorders 2020-02, Vol.35 (2), p.349-354
• Main Authors: Lee, Jee‐Young, Ahn, Jeeyun, Oh, Sohee, Shin, Joo Young, Kim, Yu Kyeong, Nam, Hyunwoo, Jeon, Beomseok
• Format: Article
• Language: English
• Subjects: Aged; Behavior disorders; biomarker; Biomarkers - analysis; Dopamine; Dopamine Plasma Membrane Transport Proteins - metabolism; Dopamine transporter; Eye movements; Female; Humans; idiopathic rapid eye movement sleep behavior disorder; Lewy bodies; Lewy body disease; Lewy Body Disease - diagnosis; Lewy Body Disease - pathology; Male; Middle Aged; Movement disorders; Neostriatum; Neurodegeneration; Neurodegenerative diseases; Olfaction; optical coherence tomography; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Parkinson's disease; Positron emission tomography; REM sleep; REM Sleep Behavior Disorder - pathology; REM Sleep Behavior Disorder - physiopathology; Retina; Retina - metabolism; Retina - pathology; Sleep disorders; Vision Disorders - diagnosis; Vision Disorders - pathology
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.27914

Objectives We investigated retinal change and its relationship with neurodegeneration markers in a prodromal Parkinson cohort. Methods A total of 30 patients with idiopathic rapid eye movement sleep behavior disorder were recruited. Participants underwent olfactory testing, macular optical coherence tomography, microperimetry, contrast sensitivity test, and brain N‐(3‐[18F]fluoropropyl)‐2‐carbomethoxy‐3‐(4‐iodophenyl) nortropane positron emission tomography. We measured the ganglion cell complex thicknesses and investigated its correlation with olfactory function and striatal dopamine transporter availability. A linear mixed‐effect model was applied with adjustment for multiple comparisons. Results The parafoveal ganglion‐cell‐complex thickness in this cohort lay between our healthy control and drug‐naïve Parkinson's disease group data. Idiopathic rapid eye movement sleep behavior disorder patients also had contrast sensitivity impairment as in Parkinson's disease with a nonsignificant change in macular sensitivities. Macular ganglion cell complex thickness correlated with olfactory scores and with striatal dopamine transporter availabilities. Conclusions Macular ganglion cell complex thinning may be a marker of neurodegeneration in prodromal Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society